Associations between Interleukin-31 Gene Polymorphisms and Dilated Cardiomyopathy in a Chinese Population.
Associations between Interleukin-31 Gene Polymorphisms and Dilated Cardiomyopathy in a Chinese Population.
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DOI：
10.1155/2017/4191365
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Rao L
中科院分区：
文献类型：
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作者：
Song H;Peng Y;Zhou B;Chen N;Xie X;Dou Q;Zhong Y;Rao L
为了探讨白细胞介素-31 （IL-31）在扩张型心肌病（DCM）中的作用，本研究分析了中国汉族人群中331例DCM患者和493例对照者中IL-31的两个snp rs4758680 （C/A）和rs7977932 （C/G）。DCM患者rs4758680 C等位基因频率和CC基因型显著升高（P = 0.005, P = 0.001，均有统计学意义）。与CC基因型rs4758680相比，CA/AA基因型是DCM易感性的保护因子，DCM组优势模型中CA/AA基因型频率降低（P < 0.001, OR = 0.56, 95%CI = 0.39 ~ 0.79）。DCM患者白细胞IL-31 mRNA表达水平升高(0.072 （0.044-0.144)vs 0.036 (0.020-0.052), P < 0.001）。在159例DCM患者的生存分析中，Kaplan-Meier曲线显示，DCM组CC纯合子rs4758680与预后差相关（P = 0.005）。与CC基因型相比，CA/AA基因型在单因素分析（HR = 0.530, 95%CI = 0.337 ~ 0.834, P = 0.006）和多因素分析（HR = 0.548, 95%CI = 0.345 ~ 0.869, P = 0.011）中均为独立因素。因此，我们认为IL-31基因多态性与DCM易感性密切相关，并与DCM患者预后不良有关。
To explore the role of Interkeulin-31 (IL-31) in dilated cardiomyopathy (DCM), in our study, two SNPs of IL-31, rs4758680 (C/A) and rs7977932 (C/G), were analyzed in 331 DCM patients and 493 controls in a Chinese Han population. The frequencies of C allele and CC genotype of rs4758680 were significantly increased in DCM patients (P = 0.005, P = 0.001, resp.). Compared to CC genotype of rs4758680, the A carriers (CA/AA genotypes) were the protect factors in DCM susceptibility while the frequencies of CA/AA genotypes were decreased in the dominant model for DCM group (P < 0.001, OR = 0.56, 95%CI = 0.39–0.79). Moreover, IL-31 mRNA expression level of white blood cells was increased in DCM patients (0.072 (0.044–0.144) versus 0.036 (0.020–0.052), P < 0.001). In survival analysis of 159 DCM patients, Kaplan-Meier curve revealed the correlation between CC homozygote of rs4758680 and worse prognosis for DCM group (P = 0.005). Compared to CC genotype, the CA/AA genotypes were the independent factors in both univariate (HR = 0.530, 95%CI = 0.337–0.834, P = 0.006) and multivariate analyses after age, gender, left ventricular end-diastolic diameter, and left ventricular ejection fraction adjusted (HR = 0.548, 95%CI = 0.345–0.869, P = 0.011). Thus, we concluded that IL-31 gene polymorphisms were tightly associated with DCM susceptibility and contributed to worse prognosis in DCM patients.