Ethanolamine-O-sulfate enhances gamma-aminobutyric acid secretion into hypophysial portal blood and lowers serum prolactin concentrations.
Ethanolamine-O-sulfate enhances gamma-aminobutyric acid secretion into hypophysial portal blood and lowers serum prolactin concentrations.
复制标题
乙醇胺-O-硫酸盐增强γ-氨基丁酸分泌到垂体门静脉血中并降低血清催乳素浓度。
DOI：
10.1159/000123580
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发表时间：
1983
影响因子：
4.1
通讯作者：
Müller,EE
中科院分区：
文献类型：
--
作者：
Gudelsky,GA;Apud,JA;Masotto,C;Locatelli,V;Cocchi,D;Racagni,G;Müller,EE
在去卵巢大鼠脑室内注射γ-氨基丁酸（GABA）转氨酶特异性竞争性催化抑制剂乙醇胺-O-硫酸盐（EOS，300 μg），3-4小时后，血清催乳素（PRL）浓度显著降低，垂体柄血浆GABA浓度升高3 - 4倍，而全身血浆GABA浓度无明显变化。EOS的管理也导致下丘脑中GABA浓度的升高。这些结果表明，垂体柄血浆中的GABA是来自中枢神经系统和垂体门静脉血中的GABA浓度的突然增加与PRL分泌的抑制。
In ovariectomized rats the intraventricular administration of ethanolamine-O-sulfate (EOS, 300 μg), a specific, competitive and catalytic inhibitor of γ-aminobutyric acid (GABA) transaminase, induced 3–4 h later a marked reduction in serum prolactin (PRL) concentrations and a 3- to 4-fold rise in the concentration of GABA in pituitary stalk, but not systemic, plasma. The administration of EOS also resulted in an elevation of GABA concentrations in the hypothalamus. These results demonstrate that GABA in pituitary stalk plasma is derived from the central nervous system and that an abrupt increase in the concentration of GABA in hypophysial portal blood is associated with a suppression of PRL secretion.