Relationship of p53 and vascular endothelial growth factor expression to clinicopathological factors in human scirrhous gastric cancer
Relationship of p53 and vascular endothelial growth factor expression to clinicopathological factors in human scirrhous gastric cancer
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DOI：
10.1159/000008568
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发表时间：
1998-03-01
影响因子：
1.6
通讯作者：
Baba, S
中科院分区：
文献类型：
--
作者：
Baba, M;Konno, H;Baba, S
虽然硬癌是胃癌中恶性潜能最高的一种，但其发病机制尚不清楚。应用免疫组化方法对40例胃硬癌组织标本进行p53和VEGF的表达与临床病理因素的关系进行了研究。p53和VEGF分别在癌细胞的胞核和胞浆中表达。p53和VEGF的表达与性别、年龄、在浸润深度、淋巴结转移或组织学分期方面，腹膜转移是最常见的复发方式，肿瘤浸润深度是决定复发的关键因素，有浆膜浸润者复发率为83.9%（26/32），无浆膜浸润者复发率为22.2%（2/9），40例患者中仅7例（17.5%）无复发，其中VEGF阳性率为14.3%（1/7），而复发患者中VEGF阳性率为52.6%（10/19）。这些结果表明，硬化性胃癌的进展可能是由VEGF过度表达，而不是上调p53突变。
Although scirrhous cancer has the highest malignant potential among various types of gastric cancer, its pathogenesis is still unclear. The relationship between expression of p53 or vascular endothelial growth factor (VEGF) and clinicopathological variables was investigated by immunohistochemical analysis of archival specimens from 40 patients with scirrhous gastric cancer, Staining for p53 and VEGF was observed in the nuclei and cytoplasm of the tumor cells, respectively, There was no significant association between expression of p53 or VEGF and sex, age, depth of invasion, lymph node metastasis or histological stage, Peritoneal dissemination was the most frequent mode of recurrence, and the depth of tumor invasion was a crucial factor, The recurrence rate was 83.9% (26/32) in patients with serosal invasion, whereas it was 22.2% (2/9) in patients without serosal invasion, Only 7 out of 40 patients (17.5%) survived without recurrence, Among them, the VEGF-positive rate was 14.3% (1/7), whereas it was 52.6% (10/19) in the patients with recurrence, There was no correlation between p53 and VEGF staining. These findings suggest that the progression of scirrhous gastric cancer may be promoted by VEGF overexpression, which is not upregulated by p53 mutation.