Changes in carbohydrate-deficient transferrin levels after alcohol withdrawal.
Changes in carbohydrate-deficient transferrin levels after alcohol withdrawal.
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戒酒后缺乏碳水化合物的转铁蛋白水平发生变化。
DOI：
10.1111/j.1530-0277.1988.tb00239.x
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Lieber,CS
中科院分区：
文献类型：
--
作者：
Behrens,UJ;Worner,TM;Lieber,CS
在72名酗酒者中，在脱毒过程中的不同时间段测定了碳水化合物缺乏型转铁蛋白（CDT）的血清水平。治疗前，57例患者（79%）CDT值增加（A组），而15例患者（21%）（B组）CDT水平在正常范围内。在51名A组患者中，CDT在停止饮酒后逐渐下降（半衰期，16 ± 5天），但在其余6名患者中波动并保持异常。B组9例患者在整个随访期间保持正常CDT值，但在其他6例B组受试者中记录到一次水平轻微或中度升高。CDT水平在治疗后达到正常值的患者，在复发后CDT表现出复发性增加。γ-谷氨酰转移酶活性在A组56%和B组80%的酗酒者中升高，在大多数初始值升高的患者中，在停止饮酒后显示出降低（A组，30/32; B组，10/12）。大多数患者的天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）活性以及平均红细胞体积（MCV）均正常。CDT/总转铁蛋白比值与CDT水平呈正相关。CDT被证明是慢性酒精中毒最敏感的标志物（79%），而GOT活性水平仅在戒酒前CDT水平正常的患者中更有用。在治疗结果的评估中，CDT和GGT作为标志物的组合产生了95%的灵敏度。
Sequential serum levels of carbohydrate‐deficient transferrin (CDT) were determined in 72 alcoholics at various intervals during detoxification. Before treatment, 57 patients (79%) had increased CDT values (Group A), whereas in 15 individuals (21%) (Group B), CDT levels were within the normal range. In 51 Group A patients, CDT decreased progressively after cessation of alcohol intake (half‐life, 16 ± 5 days), but fluctuated and remained abnormal in the remaining six. Nine Group B patients maintained normal CDT values throughout the follow‐up period, but slightly or moderately increased levels were recorded on one occasion in the other six Group B subjects. Patients whose CDT levels had reached normal values after treatment, showed a recurrent increase in CDT after a relapse. γ‐Glutamyl trensferase activities, which were elevated in 56% of Group A and in 80% of Group B alcoholics, showed a decrease after cessation of alcohol consumption in most patients with initially elevated values (Group A, 30 of 32; Group B, 10 of 12). Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities, as well as mean corpuscular volumes (MCV) were normal in the majority of patients. CDT/total transferrin ratios correlated positively with CDT levels. CDT proved to be the most sensitive marker for chronic alcoholism (79%), whereas GOT activity levels were more useful only in patients with normal CDT levels before alcohol withdrawal. In the assessment of treatment outcome, the combination of CDT and GGT as markers yielded a sensitivity of 95%.