Cancer chemopreventive activity of acridone alkaloids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis
Cancer chemopreventive activity of acridone alkaloids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis
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DOI：
10.1016/s0304-3835(03)00008-9
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发表时间：
2003-04-25
期刊：
影响因子：
9.7
通讯作者：
Furukawa, H
中科院分区：
文献类型：
--
作者：
Itoigawa, M;Ito, C;Furukawa, H
在 Raji 细胞中测试了从芸香植物中分离的 17 种吖啶酮生物碱对由 12-O-十四烷酰佛波醇-13-乙酸酯诱导的 Epstein-Barr 病毒早期抗原激活的抑制活性。一些异戊二烯化吖啶酮被发现具有非常有效的活性。根据这些体外结果合成的1,3-二羟基-10-甲基-2,4-二异戊二烯基吖啶酮(18)在体内两阶段致癌试验中对小鼠皮肤肿瘤的促进表现出显着的抑制作用。本研究的结果表明，其中一些吖啶酮生物碱可能是潜在有价值的癌症化学预防剂。 (C) 2003 Elsevier Science Ireland Ltd. 保留所有权利。
Seventeen acridone alkaloids isolated from the Rutaceous plants were tested for their inhibitory activities against Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. Some prenylated acridones were found to have remarkably potent activities. 1,3-Dihydroxy-10-methyl-2,4-diprenylacridone (18) as synthesized according to these results in vitro, exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. The result of the present investigation indicated that some of these acridone alkaloids may be potentially valuable cancer chemopreventive agents. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.