An asthma-associated genetic variant of STAT6 predicts low burden of ascaris worm infestation
An asthma-associated genetic variant of STAT6 predicts low burden of ascaris worm infestation
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DOI：
10.1038/sj.gene.6364030
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发表时间：
2004-01-01
影响因子：
5
通讯作者：
Hopkin, JM
中科院分区：
文献类型：
--
作者：
Peisong, G;Mao, XQ;Hopkin, JM
Th-2免疫机制参与哮喘病理和对寄生虫的保护性免疫反应。常见的上调Th-2免疫信号的遗传变异是哮喘的危险因素，我们测试了它们是否可能在预防寄生虫方面具有反优势。我们通过对来自中国一个地方性蛔虫感染地区的614名学童粪便中的蛔虫卵进行显微计数，检测了蛔虫感染的强度。我们研究了蛔虫感染强度与常见的哮喘相关Th-2和Th-1免疫信号遗传变异之间的关系。每克粪便蛔虫卵数（epg），平均1068 epg，范围从几乎检测不到(
Th-2 immune mechanisms are involved in the pathology of asthma and in the protective immune response to parasitic worms. Common upregulating genetic variants of Th-2 immune signalling are risk factors for asthma, and we tested whether they may confer a counteradvantage in protecting against parasitic worms. We examined the intensity of infection by the parasitic worm, Ascaris lumbricoides, by microsopic counting of ascaris eggs in the stool of 614 schoolchildren from an area of endemic ascaris infection in China. We investigated the relationship between the intensity of ascaris infection and common, asthma-associated genetic variants of Th-2 and Th-1 immune signalling. Ascaris egg counts per gram of stool (epg), mean 1068 epg, ranged from barely detectable (