Emerging concepts on T follicular helper cell dynamics in HIV infection.
Emerging concepts on T follicular helper cell dynamics in HIV infection.
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HIV 感染中滤泡辅助 T 细胞动力学的新概念。
DOI：
10.1016/j.it.2014.02.010
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发表时间：
2014
影响因子：
16.8
通讯作者：
Streeck,Hendrik
中科院分区：
文献类型：
--
作者：
Pissani,Franco;Streeck,Hendrik
通过接种疫苗诱导对HIV产生交叉反应的广谱中和抗体(BNAb)仍然是一个不可逾越的挑战。T滤泡辅助细胞(TFH)是产生抗原特异性抗体反应的基础，因此对抗HIV疫苗的设计至关重要。在这里，我们回顾了最近的研究，支持TFH细胞在HIV感染过程中复杂地参与HIV的发病机制和bNAb的发展。我们还检查了新出现的数据，表明TFHcell的反应可能在外周血中可追踪，并讨论了这些发现在疫苗设计和TFHcell免疫生物学未来研究的背景下的意义。
Inducing cross-reactive broadly neutralizing antibody (bNAb) responses to HIV through vaccination remains an insurmountable challenge. T follicular helper (TFH) cells are fundamental for the development of antigen-specific antibody responses and therefore crucial for anti-HIV vaccine design. Here, we review recent studies supporting an intricate involvement of TFHcells in HIV pathogenesis and bNAb development during HIV infection. We also examine emerging data suggesting that TFHcell responses may be traceable in peripheral blood, and discuss the implications of these findings in the context of vaccine design and future research in TFHcell immunobiology.