Epidemiology of malaria in pregnancy in central India
Epidemiology of malaria in pregnancy in central India
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印度中部妊娠期疟疾流行病学
DOI：
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发表时间：
1999
影响因子：
11.1
通讯作者：
V. Sharma
中科院分区：
文献类型：
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作者：
N. Singh;M. Shukla;V. Sharma
对印度医学研究委员会（ICMR）在印度中部贾巴尔普尔政府医学院医院运营的疟疾诊所三年数据的分析显示，孕妇中疟疾患病率较高，与非孕妇中的情况相比，具有统计学上的高度显着性（P < 0.0001）。脑型疟疾是严重恶性疟原虫感染的常见并发症，在妊娠期间死亡率很高，需要立即引起重视。研究还表明，疟疾感染在初产妇中更为常见，并且随着胎次的增加而逐渐下降。与非孕妇相比，孕妇的恶性疟原虫（P < 0.001；df = 137）和间日疟原虫（P < 0.05；df = 72）感染的平均寄生虫密度显着更高。患有恶性疟或间日疟的孕妇比未感染的孕妇或感染的非孕妇明显更贫血。感染母亲的 155 名新生儿的平均体重比未感染母亲的 175 名新生儿的平均体重轻 350 克。恶性疟原虫（P < 0.0001；df = 278）和间日疟原虫（P < 0.0001；df = 223）感染的出生体重差异具有统计学意义。没有记录先天性疟疾。我们的结论是，该地理区域的孕妇需要系统干预，因为她们在怀孕期间和产褥期对疟疾的易感性很高。
Analysis of three years of data from a malaria clinic operated by the Indian Council of Medical Research (ICMR) in the Government Medical College Hospital in Jabalpur, central India, showed a high malaria prevalence among pregnant women, which was statistically highly significant (P < 0.0001) compared with the situation among nonpregnant women. Cerebral malaria was a common complication of severe Plasmodium falciparum infection, with a high mortality during pregnancy, requiring immediate attention. The study also showed that malaria infection was more frequent in primigravidae, falling progressively with increasing parity. Mean parasite densities were significantly higher in pregnant women compared with nonpregnant women for both P. falciparum (P < 0.001; df = 137) and P. vivax (P < 0.05; df = 72) infection. Pregnant women with falciparum or vivax malaria were significantly more anaemic than noninfected pregnant women or infected nonpregnant women. The average weight of 155 neonates from infected mothers was 350 g less than that of 175 neonates from noninfected mothers. This difference in birth weight was statistically significant for both P. falciparum (P < 0.0001; df = 278) and P. vivax (P < 0.0001; df = 223) infection. Congenital malaria was not recorded. We conclude that pregnant women from this geographical area require systematic intervention owing to their high susceptibility to malaria during pregnancy and the puerperium.