Association of (pro)renin receptor gene polymorphism with blood pressure in Caucasian men
Association of (pro)renin receptor gene polymorphism with blood pressure in Caucasian men
复制标题
DOI：
10.1097/fpc.0b013e328344cdd2
复制
发表时间：
2011-06-01
影响因子：
2.6
通讯作者：
Schmieder, Roland E.
中科院分区：
文献类型：
--
作者：
Ott, Christian;Schneider, Markus P.;Schmieder, Roland E.
肾素-血管紧张素系统是心血管和肾功能的主要调节系统。近年来，（原）肾素受体[（P）RR]被鉴定为肾素-血管紧张素系统的新组分。在日本男性中，（P）RR基因的IVS 5 + 169 C> T多态性与血压（BP）相关，但在高加索人中没有数据。因此，我们对266名血压正常或轻度升高且未接受任何药物治疗的高加索男性进行了（P）RR基因IVS 5 + 169 C> T多态性的基因分型。根据现行指南测量办公室血压。（P）RR基因C等位基因携带者的静息和舒张压均低于T等位基因携带者（P < 0.05），而舒张压和心率无差异。C等位基因携带者血清醛固酮水平也低于T等位基因携带者（P < 0.05）。这些发现表明C等位基因携带者的收缩压低于T等位基因携带者。因此，我们的数据表明，（P）RR可能通过改变醛固酮的释放来影响高加索男性的血压调节。药物遗传学和基因组学21：347-349（C）2011年威科健康|利平科特威廉姆斯&威尔金斯。药物遗传学和基因组学2011，21：347-349
The renin-angiotensin system is a major regulatory system of cardiovascular and renal function. Recently, (pro) renin receptor [(P) RR] was identified as new component of the renin-angiotensin system. The IVS5+169C> T polymorphism of the (P) RR gene was shown to be associated with blood pressure (BP) in Japanese men, but no data are available for Caucasians. Hence, we genotyped the IVS5+ 169C> T polymorphism of the (P) RR gene in 266 Caucasian men with normal or mildly elevated BP and without any medication. Office BP was measured according to current guidelines. Office and resting systolic BP was lower in C-allele than in T-allele carriers (P < 0.05) of the (P) RR gene, with no difference in diastolic BP and heart rate. Serum aldosterone was also lower in C-allele than in T-allele carriers (P < 0.05). These findings indicate that C-allele carriers have lower systolic BP than T-allele carriers. Thus, our data suggest that (P) RR influences BP regulation in Caucasian men, potentially through altered aldosterone release. Pharmacogenetics and Genomics 21: 347-349 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins. Pharmacogenetics and Genomics 2011, 21: 347-349