Systemic Therapy Plus Thermal Ablation Versus Systemic Therapy Alone for Oligometastatic Liver Metastases from Non-small Cell Lung Cancer
Systemic Therapy Plus Thermal Ablation Versus Systemic Therapy Alone for Oligometastatic Liver Metastases from Non-small Cell Lung Cancer
复制标题
全身治疗加热消融与单独全身治疗治疗非小细胞肺癌寡转移性肝转移
DOI：
10.1007/s00270-020-02456-y
复制
发表时间：
2020-03-31
影响因子：
2.9
通讯作者：
Li, Xiao
中科院分区：
文献类型：
--
作者：
Zhao, Yanqing;Zhang, Xiaowu;Li, Xiao
PurposeThis study assessed and compared the efficacy and long-term outcomes of systemic therapy plus image-guided thermal ablation versus systemic therapy alone for oligometastatic liver metastases (LMs) from non-small cell lung cancer (NSCLC).Materials and MethodsThis retrospective study was approved by the institutional review board. Written informed consent was waived due to the retrospective design. From November 2012 to December 2017, 61 patients (mean age 59.0 years; 35 males) with oligometastatic LMs from NSCLC (≤ 5 metastatic lesions) who received systemic therapy with (n= 21, group A) or without (n= 40, group B) thermal ablation were analyzed. Progression-free survival (PFS) and overall survival (OS) were estimated by Kaplan–Meier curves.ResultsThe demographic and clinical characteristics were not significantly different between the groups (allP≥ .05). In total, 28 LMs were entirely ablated, rendering a technical success rate of 100%, without major complications. The overall 6-month response rate was significantly higher in group A than in group B [57.1% (12/21) vs. 26.3% (10/38);P= .026]. The median PFS in group A was significantly longer than in group B [11.0 (95% CI 7.9–16.2) months vs. 5.2 (95% CI 3.7–7.9) months;P= .001]. However, the median OS was not significantly different [27.7 (95% CI 20.6–44.4) months vs. 17.7 (95% CI 14.5–27.5) months;P= .152].ConclusionSystemic therapy plus thermal ablation may prolong PFS but not OS in oligometastatic LMs from NSCLC.
