Amyloids: friend or foe?
Amyloids: friend or foe?
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DOI：
10.3233/jad-2008-13406
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
Neal D. Hammer;Xuan Wang;B. A. McGuffie;M. Chapman
中科院分区：
文献类型：
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作者：
Neal D. Hammer;Xuan Wang;B. A. McGuffie;M. Chapman
淀粉样变是指可溶性蛋白质聚集成结构保守的纤维。淀粉样纤维的特点是对蛋白酶K的抵抗力、染色特性和富含β-折叠的二级结构。淀粉样蛋白的形成是许多人类疾病的标志，包括阿尔茨海默氏症、亨廷顿氏症和普里恩病。因此，了解淀粉样蛋白的发生将为针对这些衰弱疾病的治疗方法的发展提供洞察力。一种新的功能性淀粉样蛋白有望让人们一瞥大自然是如何利用淀粉样蛋白纤维完成重要生理任务的。功能性淀粉样蛋白是由跨越细胞生活的各个方面的生物体产生的。在此，我们回顾了淀粉样蛋白的发生，特别关注与疾病相关的淀粉样蛋白-β和几种功能性淀粉样蛋白的形成之间的异同。还将讨论研究功能性淀粉样蛋白发生的意义以及生物体用来限制接触有毒中间体的策略。
Amyloidogenesis is the aggregation of soluble proteins into structurally conserved fibers. Amyloid fibers are distinguished by their resistance to proteinase K, tinctorial properties and beta-sheet-rich secondary structure. Amyloid formation is a hallmark of many human diseases including Alzheimer's, Huntington's and the prion diseases. Therefore, understanding amyloidogenesis will provide insights into the development of therapeutics that target these debilitating diseases. A new class of ;functional' amyloids promises a unique glimpse at how nature has harnessed the amyloid fiber to accomplish important physiological tasks. Functional amyloids are produced by organisms spanning all aspects of cellular life. Herein we review amyloidogenesis, with special attention focused on the similarities and differences between the best characterized disease-associated amyloidogenic protein amyloid-beta and the formation of several functional amyloids. The implications of studying functional amyloidogenesis and the strategies organisms employ to limit exposure to toxic intermediates will also be discussed.