Atopy among schoolchildren in northern and southern Sweden in relation to pet ownership and early life events
Atopy among schoolchildren in northern and southern Sweden in relation to pet ownership and early life events
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DOI：
10.1034/j.1399-3038.2001.012001004.x
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发表时间：
2001-02-01
影响因子：
4.4
通讯作者：
Björkstén, B
中科院分区：
文献类型：
--
作者：
Bråbäck, L;Kjellman, NIM;Björkstén, B
研究表明，与斯堪的纳维亚半岛南部相比，北部地区哮喘和过敏的患病率更高。这项研究的目的是评估瑞典南部林科平和瑞典北部奥斯特松德10-11岁学龄儿童(n=2108)与宠物饲养和某些早期生活事件有关的特应性的地区差异。父母们完成了一份问卷，其中包括关于家庭环境、遗传、社会经济状况的问题，以及关于儿童哮喘和过敏症国际研究的症状的核心问题。这些孩子对8种常见的吸入性过敏原进行了皮肤点刺试验。关于母亲吸烟习惯、胎龄和人体测量的信息从瑞典医学出生登记处获得。在奥斯特松德和林科平，特应性症状和对花粉的敏感率相似。奥斯特松德儿童对动物皮屑的敏感率较高，可能与社区中宠物的发生率较高有关。目前的猫主人对猫过敏原的敏感度较低，但仅限于具有特应性遗传的儿童。体重指数30 kg/m(3)与特应性致敏风险的增加有关，在林科平(调整后的优势比2.1；95%可信区间1.1-4.0)和在奥斯特松德(调整后的优势比2.0，95%可信区间1.1-3.5)。母亲怀孕期间吸烟与林科平儿童特应性致敏风险增加有关，而目前吸烟与奥斯特松德儿童特应性致敏风险降低相关。总而言之，我们证明宠物在社区中的高发生率与致敏有关，而特应性症状基本上不受影响。这项研究还表明，出生时的身体大小和10-11岁时的特应性敏感症之间存在关联。
Studies have suggested a higher prevalence of asthma and allergies in northern, as compared to southern, Scandinavia. The aim of this study was to evaluate regional differences in atopy in relation to pet ownership and certain early life events among schoolchildren (n=2108) aged 10-11 years from Linkoping in southern Sweden and Ostersund in northern Sweden. The parents completed a questionnaire, comprising questions on home environment, heredity, socio-economic conditions, and the core questions on symptoms from the International Study of Asthma and Allergies in Childhood. The children were skin-prick tested to eight common inhalant allergens. Information on maternal smoking habits, gestational age, and anthropometric measures were obtained from the Swedish Medical Birth Registry. The prevalence of atopic symptoms and sensitization to pollen were similar in Ostersund and in Linkoping. A higher prevalence of sensitization to animal dander among children in Ostersund could be linked to a higher occurrence of pets in the community. Current cat ownership was related to less sensitivity to cat allergen but only in children with an atopic heredity. Ponderal index >30 kg/m(3) was related to an increased risk of atopic sensitization, both in Linkoping (adjusted odds ratio 2.1; 95% confidence interval 1.1-4.0) and in Ostersund (adjusted odds ratio 2.0, 95% confidence interval 1.1-3.5). Maternal smoking during pregnancy was related to an increased risk of atopic sensitization among children in Linkoping, whereas current smoking was associated with a decreased risk of sensitization in Ostersund. In conclusion, we demonstrated that a high occurrence of pets in the community was associated with sensitization, whereas atopic symptoms were essentially unaffected. This study has also suggested an association between body size at birth and atopic sensitization at 10-11 years of age.