Parsing the components of the psychomotor syndrome in schizophrenia
Parsing the components of the psychomotor syndrome in schizophrenia
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DOI：
10.1111/j.1600-0447.2012.01846.x
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发表时间：
2012-10-01
影响因子：
6.7
通讯作者：
Sabbe, B.
中科院分区：
文献类型：
--
作者：
Docx, L.;Morrens, M.;Sabbe, B.
Docx L、Morrens M、Bervoets C、Hulstijn W、Fransen E、De Hert M、Baeken C、Audenaert K、Sabbe B。解析精神分裂症精神运动综合征的组成部分。目的：紧张症、锥体外系体征、精神运动减慢和（运动）神经软体征是精神分裂症中众所周知的精神运动症状。本研究旨在调查这些症状之间的相互关系。此外，还将研究精神运动症状、临床症状和认知功能之间的关联。方法：一系列广泛的测试，包含精神运动（布什弗朗西斯紧张症评定量表；圣汉斯评定量表；沙尔佩特里尔迟滞评定量表；神经学评估量表）和临床（阳性和阴性综合症量表；卡尔加里抑郁量表）评定量表以及仪器性精神运动测试（抄行任务；手指敲击任务）和认知任务（符号数字替换测试；斯特鲁普色词测试；连续表现测试；字母）对 124 名精神分裂症或分裂情感障碍患者的样本进行了数字测序。结果：相关分析显示，我们的数据中出现了两个聚类：首先，精神运动贫困聚类指的是紧张症、帕金森病、精神运动减慢和阴性症状之间的相互关系；其次，包含运动神经软体征的簇，被发现与认知功能相关。结论：精神运动异常是精神分裂症中非常普遍的现象，必须将其视为异质结构。然而，需要纵向和神经生物学研究来进一步探索本研究中发现的相互关系的确切性质。
Docx L, Morrens M, Bervoets C, Hulstijn W, Fransen E, De Hert M, Baeken C, Audenaert K, Sabbe B. Parsing the components of the psychomotor syndrome in schizophrenia. Objective: Catatonia, extrapyramidal signs, psychomotor slowing, and (motoric) neurological soft signs are well-known psychomotor symptoms in schizophrenia. This study aims at investigating the interrelations between these symptoms. In addition, associations between psychomotor symptoms, clinical symptoms, and cognitive functioning will be studied. Method: An extensive test battery containing psychomotor (Bush Francis Catatonia Rating Scale; St Hans Rating Scale; Salpetriere Retardation Rating Scale; Neurological Evaluation Scale) and clinical (Positive and Negative Syndrome Scale; Calgary Depression Scale) rating scales as well as instrumental psychomotor tests (Line Copying Task; Finger Tapping Task) and cognitive tasks (Symbol Digit Substitution Test; Stroop Colour Word Test; Continuous Performance Test; Letter Number Sequencing) was administered to a sample of 124 patients with schizophrenia or schizoaffective disorder. Results: Correlational analyses showed that two clusters emerge from our data: first, a psychomotor poverty cluster referring to the interrelations between catatonia, parkinsonism, psychomotor slowing, and negative symptoms; second, a cluster containing motoric neurological soft signs, which were found to be correlated with cognitive functioning. Conclusion: Psychomotor abnormalities are highly prevalent phenomena in schizophrenia that have to be considered as a heterogeneous construct. However, longitudinal and neurobiological research is needed to further explore the precise nature of the interrelations found in this study.