To do or not to do: The neural signature of self-control
To do or not to do: The neural signature of self-control
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DOI：
10.1523/jneurosci.0924-07.2007
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发表时间：
2007-08-22
影响因子：
5.3
通讯作者：
Haggard, Patrick
中科院分区：
文献类型：
--
作者：
Brass, Marcel;Haggard, Patrick
志愿行动是人类生存的根本。最近的研究表明，意志涉及一个特定的大脑活动网络，集中在额中皮层。有意识行动的一个重要但被忽视的方面涉及是否行动的决定。这个决策过程在日常生活中至关重要，因为它允许我们形成意图，而不必实施它们。在本研究中，我们使用功能性磁共振成像来研究有意抑制行为的神经相关性。我们的数据显示，当人们准备手动动作，然后故意取消它们时，与他们准备然后完成相同动作时相比，额中皮层的一个特定区域被更强烈地激活。我们的研究结果表明，人脑网络的有意行动包括一个控制结构的自我发起的抑制或扣留的预期行动。对行为的精神控制有着持久的科学兴趣，与“自由意志”的哲学概念有关。“我们的研究结果确定了一个候选大脑区域，它反映了做或不做的关键决定。
Voluntary action is fundamental to human existence. Recent research suggests that volition involves a specific network of brain activity, centered on the fronto-median cortex. An important but neglected aspect of intentional action involves the decision whether to act or not. This decision process is crucial in daily life because it allows us to form intentions without necessarily implementing them. In the present study, we investigate the neural correlates of intentionally inhibiting actions using functional magnetic resonance imaging. Our data show that a specific area of the fronto-median cortex is more strongly activated when people prepare manual actions but then intentionally cancel them, compared with when they prepare and then complete the same actions. Our results suggest that the human brain network for intentional action includes a control structure for self-initiated inhibition or withholding of intended actions. The mental control of action has an enduring scientific interest, linked to the philosophical concept of "free will." Our results identify a candidate brain area that reflects the crucial decision to do or not to do.