P66SHC and ageing: ROS and TOR?
P66SHC and ageing: ROS and TOR?
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DOI：
10.18632/aging.100182
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发表时间：
2010-08
期刊：
影响因子：
--
通讯作者：
Pani G
中科院分区：
文献类型：
--
作者：
Pani G
活性氧物种(ROS)和营养敏感的mTOR/S6激酶通路的过度激活都与衰老和与年龄相关的疾病以及限制热量的抗衰老作用有关。最近的研究发现，促进衰老和促进氧化的分子p66shc有助于营养物质激活S6K，并促进小鼠的胰岛素抵抗和糖尿病，这可能为“ROS或TOR？”提供了答案。进退两难。
Both Reactive Oxygen Species (ROS) and hyperactivation of the nutrient-sensing mTOR/S6 kinase cascade have been linked to aging and age-related diseases as well as to the anti-aging effect of calorie restriction. Recent findings that the pro-aging and pro-oxidant molecule p66shc contributes to S6K activation by nutrients and promotes insulin resistance and diabetes in mice may provide an answer to the "ROS or TOR?" dilemma.