Sex Differences in the Incidence and Clearance of Anogenital Human Papillomavirus Infection in Liuzhou, China: An Observational Cohort Study
Sex Differences in the Incidence and Clearance of Anogenital Human Papillomavirus Infection in Liuzhou, China: An Observational Cohort Study
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中国柳州肛门生殖器人乳头瘤病毒感染的发病率和清除率的性别差异：一项观察性队列研究。
DOI：
10.1093/cid/ciz168
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发表时间：
2020-01-01
影响因子：
11.8
通讯作者：
Xia，Ningshao
中科院分区：
文献类型：
--
作者：
Wei，Feixue;Guo，Meng;Xia，Ningshao
人类乳头瘤病毒（HPV）可引起男性和女性的肛门生殖器疣和癌症。然而，鲜为人知的是，关于肛门生殖器HPV infection.MethodsStarting在2014年5月的自然史的性别差异，包括2309名男性和2378名女性年龄在18-55岁的观察性队列研究在中国柳州进行。采用实时荧光定量聚合酶链反应（PCR）和熔解曲线分析技术，每半年检测一次肛门生殖器部位的HPV基因型，共检测1年。（10.3和11.5/1000人月;P= 0.275），而男性HPV-6/11感染的发生率高于女性（2.0 vs 1.1;P= 0.018）。在18- 25岁年龄组的女性中，致癌HPV和HPV-6/11感染的发病率显著高于年龄较大的女性（分别为P= 0.006和0.011），而男性中的发病率则没有随年龄而变化（分别为P= 0.552和0.425）。此外，男性比女性更有可能清除致癌感染（101.5 vs 58.6/1000人月;P<0.001），但在HPV-6/11的清除率方面没有发现性别差异（111.7 vs 84.8;P= 0.266）。致癌型和6/11型感染的中位清除时间与性别无关（均P> 0.05）。结论致癌和非致癌HPV感染的自然史因性别而异，这意味着应考虑针对致癌和非致癌HPV的性别特异性疫苗接种策略。
BackgroundHuman papillomavirus (HPV) causes anogenital warts and cancers in men and women. However, little is known about sex differences regarding the natural history of anogenital HPV infection.MethodsStarting in May 2014, an observational cohort study including 2309 men and 2378 women aged 18–55 years was conducted in Liuzhou, China. Samples from anogenital sites were tested for HPV genotypes by multicolor real-time polymerase chain reaction and melting curve analysis biannually for ~1 year.ResultsThe incidence of oncogenic HPV infection was similar in men and women (10.3 and 11.5/1000 person-months;P= .275), whereas the incidence of HPV-6/11 infection was higher in men than in women (2.0 vs 1.1;P= .018). The incidence of both oncogenic HPV and HPV-6/11 infections was significantly higher in women in the 18- to 25-year age group than in the older age groups (P= .006 and .011, respectively), whereas it did not vary by age among men (P= .552 and .425, respectively). Additionally, men were more likely than women to clear oncogenic infections (101.5 vs 58.6/1000 person-months;P< .001), but no significant difference was found in the clearance of HPV-6/11 by sex (111.7 vs 84.8;P= .266). The median time to clearance of oncogenic type and type 6/11 infections was not age dependent for either sex (allP> .05).ConclusionsThe natural history of oncogenic and nononcogenic HPV infection differs by sex, which implies that sex-specific vaccination strategies should be considered for oncogenic and nononcogenic HPV.Clinical Trials RegistrationNCT02188004.