Research on establishment of abnormal phlegmatic syndrome with premature ovarian failure rat model and effects of abnormal Balgham Munziq treatment
Research on establishment of abnormal phlegmatic syndrome with premature ovarian failure rat model and effects of abnormal Balgham Munziq treatment
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Adilijiang Yiming
中科院分区：
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作者：
Xiamixinuer Yilike;Abulizi Keremu;Aziguli Yaoliwasi;Mayire Tuerhong;Nafeisha Kadeer;Heyi;Adilijiang Yiming
The purposes of this study were to establish and to explore the biological basis of the chronic stress induced premature ovarian failure (POF) model, also to explore the therapeutic effects of the traditional Chinese medicine Munziq. Sexually matured female SD rats were fed with spinach and cilantro in cold and wet conditions for about 20 weeks, until a chronic stress (CS) model was established. CS rats were divided into POF stress model group and stress model group according to weekly biological characteristics and hormone level detection (LH, FSF and E2). To investigate the therapeutic effect of Munziqi, the POF disease stress model group was divided into the high, medium and low drug intervention groups. The results showed that chronic stresses (special food, cold, damp) can lead to POF disease; Traditional Chinese medicine Munziq not only improve the reproductive hormone level disorder, but also improve the function of the hypothalamus-pituitary-ovarian axis, its mechanism may be a change E2, LH and FSH hormone levels in serum and lower the expression of ovarian premature aging related protein PFN-1....
