A gut-vascular barrier controls the systemic dissemination of bacteria
A gut-vascular barrier controls the systemic dissemination of bacteria
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DOI：
10.1126/science.aad0135
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发表时间：
2015-11-13
期刊：
影响因子：
56.9
通讯作者：
Rescigno, Maria
中科院分区：
文献类型：
--
作者：
Spadoni, Ilaria;Zagato, Elena;Rescigno, Maria
在健康个体中，肠道微生物群不能进入肝脏、脾脏或其他外周组织。然而，一些病原菌可以到达这些部位，并可以诱导全身免疫反应。这种划分是如何实现的尚不清楚。我们在小鼠和人类中发现了一种肠血管屏障（GVB），它控制抗原转移到血液中，并阻止微生物群进入。鼠伤寒沙门氏菌可以穿透GVB的方式依赖于其致病性岛（Spi）2编码的III型分泌系统和减少β-连环蛋白依赖性信号在肠道内皮细胞。GVB在血清转氨酶升高的乳糜泻患者中被修饰，这表明GVB分解可能是这些患者肝损伤的原因。了解GVB可能为肠-肝轴的调节提供新的见解。
In healthy individuals, the intestinal microbiota cannot access the liver, spleen, or other peripheral tissues. Some pathogenic bacteria can reach these sites, however, and can induce a systemic immune response. How such compartmentalization is achieved is unknown. We identify a gut-vascular barrier (GVB) in mice and humans that controls the translocation of antigens into the bloodstream and prohibits entry of the microbiota. Salmonella typhimurium can penetrate the GVB in a manner dependent on its pathogenicity island (Spi) 2-encoded type III secretion system and on decreased beta-catenin-dependent signaling in gut endothelial cells. The GVB is modified in celiac disease patients with elevated serum transaminases, which indicates that GVB dismantling may be responsible for liver damage in these patients. Understanding the GVB may provide new insights into the regulation of the gut-liver axis.