Biochemistry of late effects in rat lung after hemithoracic irradiation.
Biochemistry of late effects in rat lung after hemithoracic irradiation.
复制标题
半胸照射后大鼠肺迟发效应的生物化学。
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
G. Casale
中科院分区：
文献类型：
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作者：
G. Gerber;A. Dancewicz;B. Bessemans;G. Casale
用1kR的X线照射大鼠右胸，在不同时间处死动物，测定照射后1天至11个月的各种生理生化指标（DNA、蛋白质、胶原、唾液酸、溶酶体酶、纤溶活性、过氧化物和照射肺与未照射肺的血流量比）。相对血流量的减少，观察到从2周至11个月，减少磷脂从1个月至3个月和减少纤维蛋白溶解活性从1天至11个月后照射。还观察到唾液酸和组织蛋白酶D多次降低。的变化进行了讨论，相对于晚期肺损伤的发病机制。
The right hemithorax of rats was exposed to 1 kR of roentgen rays, the animals were killed at different times, and various physiologic and biochemic parameters (DNA, protein, collagen, sialic acid, lysosomal enzymes, fibrinolytic activity, peroxides and blood flow ratio between irradiated and non irradiated lung) were determined from 1 day until 11 months after irradiation. A decrease in relative blood flow was observed from 2 weeks until 11 months, a decrease in phospholipids from one to 3 months and a decrease in fibrinolytic activity from 1 day to 11 months after irradiation. At several times a decrease in sialic acid and cathepsin D was also noted. The changes are discussed with respect to the pathogenetic mechanisms of late lung damage.