The photoreactivity of ocular lipofuscin
The photoreactivity of ocular lipofuscin
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DOI：
10.1039/b400108g
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发表时间：
2004-01-01
影响因子：
3.1
通讯作者：
Wess, T
中科院分区：
文献类型：
--
作者：
Boulton, M;Rózanowska, M;Wess, T
其在全身的各种有丝分裂后代谢活性细胞中积累。这些复合物被认为是由氧化底物的不完全降解引起的，具有光反应性的潜力。在视网膜中尤其如此，其中脂褐质不仅含有类维生素A代谢物，而且还暴露于高氧和可见光通量，所有这些都为活性氧物质（ROS）的产生提供了理想的环境。脂褐素是一种有效的光诱导ROS生成剂，具有破坏蛋白质、脂质和DNA的潜力。视网膜细胞功能障碍可能与脂褐质的光反应性密切相关，并可能导致年龄相关疾病和视力丧失。
which accumulates in a variety of postmitotic, metabolically active cells throughout the body. These complexes, which are thought to result from the incomplete degradation of oxidised substrate, have the potential for photoreactivity. This is particularly so in the retina in which the lipofuscin not only contains retinoid metabolites but is also exposed to high oxygen and fluxes of visible light all of which provide an ideal environment for the generation of reactive oxygen species (ROS). Lipofuscin is a potent photoinducible generator of ROS with the potential to damage proteins, lipids and DNA. Retinal cell dysfunction may be strongly associated with photoreactivity of lipofuscin and may contribute to age-related disease and vision loss.