Modulation of BMP signaling by noggin is required for induction of the secondary (Nontylotrich) hair follicles
Modulation of BMP signaling by noggin is required for induction of the secondary (Nontylotrich) hair follicles
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DOI：
10.1046/j.1523-1747.2002.01645.x
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发表时间：
2002-01-01
影响因子：
6.5
通讯作者：
Gilchrest, BA
中科院分区：
文献类型：
--
作者：
Botchkarev, VA;Botchkareva, NV;Gilchrest, BA
越来越多的证据表明，来自同一器官的承诺上皮的不同发育结构的形态发生是由不同的机制控制。正如最近在无绒毛（dL）基因突变的小鼠中所显示的那样，初级毛囊或多毛毛囊的诱导明显依赖于通过TNF受体同源物Edar的信号传导。在这里，我们表明，背部皮肤的小鼠胚胎与组成性缺失的BMP 2/4拮抗剂头蛋白，移植到SCID小鼠后，其特征在于缺乏诱导的次级毛囊，并通过逮捕的初级毛囊发育之前，毛干形成。头蛋白活性的丧失与不能表达指定表皮（Lef-1，β-betacatenin，Shh）和真皮乳头（p75 kDa神经营养因子受体，碱性磷酸酶）中毛囊细胞命运的基因有关。这表明，通过noggin调节BMP 2/4信号传导对于诱导次级毛囊以及初级毛囊发育的高级阶段是必需的。
Increasing evidence suggests that morphogenesis of the distinct developmental structures derived from the same organ-committed epithelium is controlled by differential mechanisms. As was recently shown in mice with mutations in the downless (dL) gene, induction of primary or tylotrich hair follicles is strikingly dependent of signaling through the Tnf receptor homologue, Edar. Here, we show that dorsal skin of murine embryos with constitutive deletion of the BMP2/4 antagonist noggin, after transplantation into SCID mice, is characterized by the lack of induction of secondary hair follicles, and by the arrest of primary hair follicle development prior to hair shaft formation. The loss of noggin activity was associated with failure to express genes that specify hair follicle cell fates in the epidermis (Lef-1, -betacatenin, Shh) and dermal papilla (p75 kDa neurotrophin receptor, alkaline phosphatase). This suggests that regulation of BMP2/4 signaling by noggin is essential for the induction of secondary hair follicles, as well as for advanced stages of development in primary hair follicles.