Version 3 of the National Alzheimer's Coordinating Center's Uniform Data Set.
Version 3 of the National Alzheimer's Coordinating Center's Uniform Data Set.
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DOI：
10.1097/wad.0000000000000279
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发表时间：
2018-10
影响因子：
2.1
通讯作者：
Neuropsychology Work Group, Directors, and Clinical Core leaders of the National Institute on Aging-funded US Alzheimer’s Disease Centers
中科院分区：
文献类型：
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作者：
Besser L;Kukull W;Knopman DS;Chui H;Galasko D;Weintraub S;Jicha G;Carlsson C;Burns J;Quinn J;Sweet RA;Rascovsky K;Teylan M;Beekly D;Thomas G;Bollenbeck M;Monsell S;Mock C;Zhou XH;Thomas N;Robichaud E;Dean M;Hubbard J;Jacka M;Schwabe-Fry K;Wu J;Phelps C;Morris JC;Neuropsychology Work Group, Directors, and Clinical Core leaders of the National Institute on Aging-funded US Alzheimer’s Disease Centers
补充数字内容可在文本中找到。2015年，美国阿尔茨海默病中心（ADC）实施了统一数据集（UDS）的第3版。本文介绍了第3版的发展历史和UDS数据，可免费提供给研究人员。UDS第3版是在国家老龄化研究所指定的临床工作组（CTF），来自1030个ADC的临床医生和国家阿尔茨海默病协调中心（NACC）之间多年协调后开发的。CTF认识到需要更新以与痴呆症研究的科学状态保持一致，同时灵活应对ADC研究的各种需求和疾病。第三版还开发了一套非专利的神经心理学电池。本文重点介绍了与临床诊断和临床症状表征相关的UDS表格第3版的实质性变更，以匹配更新的基于共识的诊断标准。在2015年3月至2018年3月期间，使用UDS第3版招募了4820名参与者。使用所有UDS版本的37，568名参与者中有25，337名可获得纵向数据。使用UDS的结果突出了许多研究机构成功合作，生产和使用标准化数据收集工具的可能性超过十年。
Supplemental Digital Content is available in the text. In 2015, the US Alzheimer’s Disease Centers (ADC) implemented Version 3 of the Uniform Data Set (UDS). This paper describes the history of Version 3 development and the UDS data that are freely available to researchers. UDS Version 3 was developed after years of coordination between the National Institute on Aging-appointed Clinical Task Force (CTF), clinicians from ∼30 ADCs, and the National Alzheimer’s Coordinating Center (NACC). The CTF recognized the need for updates to align with the state of the science in dementia research, while being flexible to the diverse needs and diseases studied at the ADCs. Version 3 also developed a nonproprietary neuropsychological battery. This paper focuses on the substantial Version 3 changes to the UDS forms related to clinical diagnosis and characterization of clinical symptoms to match updated consensus-based diagnostic criteria. Between March 2015 and March 2018, 4820 participants were enrolled using UDS Version 3. Longitudinal data were available for 25,337 of the 37,568 total participants using all UDS versions. The results from utilization of the UDS highlight the possibility for numerous research institutions to successfully collaborate, produce, and use standardized data collection instruments for over a decade.