Novel Disposable Transnasal Endoscopy for Assessment of Esophageal Motor Function
Novel Disposable Transnasal Endoscopy for Assessment of Esophageal Motor Function
复制标题
用于评估食管运动功能的新型一次性经鼻内窥镜
DOI：
10.1097/mcg.0b013e3182a8810a
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发表时间：
2013
影响因子：
2.9
通讯作者：
Kyu
中科院分区：
文献类型：
--
作者：
C. Lim;Myung;M. Baeg;S. Moon;J. Kim;Yukiko Cho;J. Park;I. Lee;S. Kim;Kyu
背景资料：开发了一种新型便携式一次性经鼻内窥镜（DTE），通过改良胶囊式内窥镜提供非镇静食管镜检查。本研究的目的是评估DTE评估食管运动功能的可行性。材料与方法：食管动力障碍或可疑食管动力障碍患者和健康志愿者。参与者在不同的日子以随机顺序接受食管高分辨率测压和DTE。在胃食管交界处上方1、8和16 cm处观察DTE的运动性。结果如下：20名健康志愿者和20名有症状的受试者参与了研究（8名贲门失弛缓症受试者、5名硬皮病受试者、3名弥漫性食管痉挛受试者、1名高血压性食管炎受试者、1名蠕动功能障碍受试者和22名食管功能正常受试者）。DTE的正常结果如下。当受试者吞咽水时，吞咽引起的舒张伴食管下括约肌升高导致内窥镜穿过Z线进入胃腔。在水和空气通过后，下食管括约肌完全闭合，内窥镜返回到其先前位置。在食管体静止期，在径向褶皱和闭塞的管腔中心可以看到气泡。内镜诊断与临床诊断一致，2例除外。大多数受试者报告DTE期间的不适可接受，62.5%的受试者首选DTE而不是测压。结论：DTE能准确反映正常食管运动功能，有助于食管动力障碍的诊断。DTE具有潜在的广泛应用，特别是在门诊。
Background: A novel disposable transnasal endoscopy (DTE) with a portable system has been developed to provide unsedated esophagoscopy by modifying capsule endoscopy. The aim of this study was to assess the feasibility of DTE to evaluate esophageal motor function. Materials and Methods: Patients with or suspected esophageal motility disorders and healthy volunteers were enrolled. Participants underwent esophageal high-resolution manometry and DTE in random order on different days. Motility was observed with DTE at 1, 8, and 16 cm above the gastroesophageal junction. Results: Twenty healthy volunteers and 20 symptomatic subjects participated (8 achalasia, 5 scleroderma, 3 diffuse esophageal spasm, 1 hypertensive peristalsis, 1 peristaltic dysfunction, and 22 normal esophageal function). The normal findings on DTE were as follows. As the subject swallowed water, swallow-induced relaxation with elevation of the lower esophageal sphincter caused the endoscope to cross the Z-line into the gastric lumen. After the passage of water and air, complete closure of the lower esophageal sphincter occurred, with the return of the endoscope to its previous position. During the resting stage of the esophageal body, an air bubble could be seen in the center of the radially wrinkled and occluded lumen. The endoscopic diagnosis was in agreement with the clinical diagnosis in all but 2. Most of the participants reported acceptable discomfort during DTE and 62.5% of the subjects preferred DTE to manometry. Conclusions: DTE can accurately characterize normal esophageal motor function, allowing the diagnosis of esophageal motility disorders. DTE has potential widespread applications, especially in outpatient clinics.