Mitochondrial genome dynamics in plants and animals:: Convergent gene fusions of a MutS homologue
Mitochondrial genome dynamics in plants and animals:: Convergent gene fusions of a MutS homologue
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DOI：
10.1007/s00239-005-0226-9
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发表时间：
2006-08-01
影响因子：
3.9
通讯作者：
Mackenzie, Sally A.
中科院分区：
文献类型：
--
作者：
Abdelnoor, Ricardo V.;Christensen, Alan C.;Mackenzie, Sally A.
线粒体过程影响高等真核生物的广泛生理和发育事件，其异常功能可导致哺乳动物中几种常见的疾病表型。在植物中，线粒体基因直接影响花粉发育和自然植物群体中雄性不育的发生。同样，在动物系统中，积累的证据表明线粒体在精子发生和生殖中具有重要的功能。在这里，我们提供了收敛基因融合的证据，该融合涉及在线粒体内发挥作用的 MutS 同源基因，并指定为 Msh1。仅在植物和软珊瑚中，MutS 同源物与蛋白质羧基末端的归巢核酸内切酶序列融合。然而，植物和软珊瑚中的核酸内切酶结构域是不同类群的成员。在植物中，Msh1 可以影响线粒体基因组组织和雄性不育表达。基于植物和珊瑚共有的 Msh1 基因结构的相似性以及它们在繁殖行为上的相似性，我们假设这种趋同的基因融合可能是为了响应繁殖的一致适应性压力而发生的。
Mitochondrial processes influence a broad spectrum of physiological and developmental events in higher eukaryotes, and their aberrant function can lead to several familiar disease phenotypes in mammals. In plants, mitochondrial genes directly influence pollen development and the occurrence of male sterility in natural plant populations. Likewise, in animal systems evidence accumulates to suggest important mitochondrial functions in spermatogenesis and reproduction. Here we present evidence for a convergent gene fusion involving a MutS-homologous gene functioning within the mitochondrion and designated Msh1. In only plants and soft corals, the MutS homologue has fused with a homing endonuclease sequence at the carboxy terminus of the protein. However, the endonuclease domains in the plants and the soft corals are members of different groups. In plants, Msh1 can influence mitochondrial genome organization and male sterility expression. Based on parallels in Msh1 gene structure shared by plants and corals, and their similarities in reproductive behavior, we postulate that this convergent gene fusion might have occurred in response to coincident adaptive pressures on reproduction.