The polysaccharide-peptide complex from mushroom Cordyceps militaris ameliorates atherosclerosis by modulating the lncRNA-miRNA-mRNA axis
The polysaccharide-peptide complex from mushroom Cordyceps militaris ameliorates atherosclerosis by modulating the lncRNA-miRNA-mRNA axis
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DOI：
10.1039/d1fo03285b
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发表时间：
2022-02-22
期刊：
影响因子：
6.1
通讯作者：
Guo, Shou-Dong
中科院分区：
文献类型：
--
作者：
Li, Yuan;Miao, Miao;Guo, Shou-Dong
从黑木耳子实体中分离得到一种N-糖苷多糖-肽复合物CMPS-80。军队。重要的是，CMPS-80显着改善载脂蛋白E缺陷小鼠动脉粥样硬化病变和血脂谱的形成。综合信息学分析表明，CMPS-80可以调节多个lncRNA-microRNA-mRNA轴。CMPS-80在预防高脂血症和动脉粥样硬化方面具有潜在的应用价值。
An N-glycosidic polysaccharide-peptide complex CMPS-80 was obtained from the fruiting body of C. militaris. Of importance, CMPS-80 significantly ameliorated formation of atherosclerotic lesions and plasma lipid profiles in apolipoprotein E-deficient mice. Integrated informatics analysis suggested that CMPS-80 can modulate multiple lncRNA-microRNA-mRNA axes. CMPS-80 has a potential application for prevention of hyperlipidemia and atherosclerosis.