Circadian differences in behavioral sensitization to cocaine: putative role of arylalkylamine N-acetyltransferase.
Circadian differences in behavioral sensitization to cocaine: putative role of arylalkylamine N-acetyltransferase.
复制标题
可卡因行为敏感性的昼夜节律差异：芳基烷基胺 N-乙酰转移酶的推定作用。
DOI：
10.1016/s0024-3205(02)01559-x
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发表时间：
2002
期刊：
影响因子：
6.1
通讯作者：
Manev,Hari
中科院分区：
文献类型：
--
作者：
Uz,Tolga;Javaid,JavaidI;Manev,Hari
昼夜节律可能与成瘾行为有关。松果体分泌产物褪黑激素降低大鼠对可卡因的敏感性;关键褪黑激素合成酶芳基烷基胺N-乙酰转移酶（AANAT）突变的小鼠表现出行为改变。我们假设AANAT/褪黑激素系统，这是在夜间上调，影响可卡因致敏小鼠。腹膜内可卡因治疗（10和20 mg/kg）剂量依赖性地增加正常（C3 H/HeJ）和AANAT突变（C57 BL/6 J）小鼠的自发活动，这种效果在白天和夜间相似。在白天注射可卡因三天导致正常和AANAT突变小鼠的行为致敏，而在夜间治疗仅在AANAT缺陷小鼠中引发致敏。AANAT的表达和N-乙酰5-羟色胺/褪黑激素的合成可能在可卡因成瘾特性中发挥作用。
Circadian rhythms might be involved in addictive behaviors. The pineal secretory product melatonin decreases cocaine sensitization in rats; mice mutant for the critical melatonin-synthesizing enzyme, arylalkylamine N-acetyltransferase (AANAT), exhibit altered behaviors. We hypothesized that AANAT/melatonin system, which is up-regulated at night, affects cocaine sensitization in mice. Intraperitoneal cocaine treatment (10 and 20 mg/kg) dose-dependently increased locomotor activity of both normal (C3H/HeJ) and AANAT mutant (C57BL/6J) mice; this effect was similar during the day and at night. Injections of cocaine during the day for three days resulted in behavioral sensitization in normal and AANAT mutant mice whereas treatment at night triggered sensitization in AANAT-deficient mice only. AANAT expression and synthesis of N-acetylserotonin/melatonin could play a role in addictive properties of cocaine.