Farnesoid X receptor, the bile acid sensing nuclear receptor, in liver regeneration.
Farnesoid X receptor, the bile acid sensing nuclear receptor, in liver regeneration.
复制标题
Farnesoid X 受体，胆汁酸传感核受体，在肝再生中。
DOI：
10.1016/j.apsb.2015.01.005
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
L Guo G
中科院分区：
文献类型：
--
作者：
Li G;L Guo G
肝脏具有独特的再生潜力，可以恢复因缺血和切除而失去的体积和功能。肝脏再生的潜在分子机制已经在过去使用啮齿动物部分肝切除术（PH）模型进行了广泛的研究，其中2/3的PH是通过切除两个叶来进行的。肝脏再生的整个过程是一个复杂的、精心策划的事件，涉及一个相互作用的网络，这仍然是完全难以捉摸的。胆汁酸（BAs）是farnesoid X受体（FXR）的配体，FXR是配体激活转录因子的核受体。FXR已被证明与肝脏再生密切相关。在肝脏再生过程中，BAs和FXR不仅相互作用，还独立调控各种下游靶标。此外，最近的研究结果表明，组织特异性FXR也显著促进肝脏再生。这些新发现表明，FXR具有比调节BA、胆固醇、脂质和葡萄糖代谢更广泛的作用。因此，这些研究突出了FXR作为一个重要的药物靶点，有可能在临床应用FXR配体调节肝脏再生。本文综述了BAs和FXR在肝脏再生中的作用以及目前促进肝脏再生的潜在分子机制。本文综述了胆汁酸（BAs）和法内酯X受体（FXR）在肝脏再生中的作用，以及目前促进肝脏再生的潜在分子机制。
The liver is unique in regenerative potential, which could recover the lost mass and function after injury from ischemia and resection. The underlying molecular mechanisms of liver regeneration have been extensively studied in the past using the partial hepatectomy (PH) model in rodents, where 2/3 PH is carried out by removing two lobes. The whole process of liver regeneration is complicated, orchestrated event involving a network of connected interactions, which still remain fully elusive. Bile acids (BAs) are ligands of farnesoid X receptor (FXR), a nuclear receptor of ligand-activated transcription factor. FXR has been shown to be highly involved in liver regeneration. BAs and FXR not only interact with each other but also regulate various downstream targets independently during liver regeneration. Moreover, recent findings suggest that tissue-specific FXR also contributes to liver regeneration significantly. These novel findings suggest that FXR has much broader role than regulating BA, cholesterol, lipid and glucose metabolism. Therefore, these researches highlight FXR as an important pharmaceutical target for potential use of FXR ligands to regulate liver regeneration in clinic. This review focuses on the roles of BAs and FXR in liver regeneration and the current underlying molecular mechanisms which contribute to liver regeneration. This review focuses on the roles of bile acids (BAs) and farnesoid X receptor (FXR) in liver regeneration and the current underlying molecular mechanisms which contribute to liver regeneration.