Colloidal crystal microneedle patch for glucose monitoring
Colloidal crystal microneedle patch for glucose monitoring
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DOI：
10.1016/j.nantod.2020.100984
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发表时间：
2020-12
期刊：
影响因子：
17.4
通讯作者：
Yi Zeng;Jinqiang Wang;Zejun Wang;Guojun Chen;Jicheng Yu;Sen Li;Qiwei Li;Hongjun Li;Di Wen;Zhongze Gu;Zheng Gu
中科院分区：
文献类型：
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作者：
Yi Zeng;Jinqiang Wang;Zejun Wang;Guojun Chen;Jicheng Yu;Sen Li;Qiwei Li;Hongjun Li;Di Wen;Zhongze Gu;Zheng Gu
血糖监测是 1 型或晚期 2 型糖尿病患者的日常工作。为了提高患者的依从性，需要努力减少现有血糖监测设备的侵入性、提高便携性和增强可持续性。在这里，我们描述了一种用于肉眼血糖监测的微创胶体晶体微针（MN）贴片。葡萄糖响应胶体晶体 (GCC)-MN 设计有聚合物核心，以机械方式支撑 GCC 外壳，用于葡萄糖传感和报告。 GCC-MN贴片可以在5分钟内将葡萄糖浓度转化为肉眼可辨别的颜色变化，并且这种葡萄糖反应是可逆的。在 1 型糖尿病小鼠模型中，该 GCC-MN 贴片可同时实现间质液提取、葡萄糖传感以及由此产生的葡萄糖相关彩色显示程序。
Blood glucose monitoring is a daily routine of people with type 1 or advanced type 2 diabetes. Efforts on minimizing invasiveness, improving portability, and enhancing sustainability of the existing glucose monitoring devices are demanding for elevating patient compliance. Here, we describe a minimally invasive colloidal crystal microneedle (MN) patch for naked-eye glucose monitoring. The glucose-responsive colloidal crystal (GCC)-MN is designed with a polymeric core to mechanically support a shell of GCC for glucose sensing and reporting. The GCC-MN patch could translate the glucose concentrations into naked-eye distinguishable color changes within 5 min, and such glucose responsiveness is reversible. Demonstrated in a type 1 diabetic mouse model, the interstitial fluid extraction, glucose sensing, and resulting glucose-relevant color display procedures are simultaneously achieved with this GCC-MN patch.