Food-Borne Origins of Escherichia coli Causing Extraintestinal Infections
Food-Borne Origins of Escherichia coli Causing Extraintestinal Infections
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DOI：
10.1093/cid/cis502
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发表时间：
2012-09-01
影响因子：
11.8
通讯作者：
Johnson, James R.
中科院分区：
文献类型：
--
作者：
Manges, Amee R.;Johnson, James R.
大多数人类肠外大肠杆菌感染，包括那些涉及抗菌素耐药菌株的感染，是由数量有限的独特大肠杆菌谱系的成员引起的，称为肠外致病性大肠杆菌（ExPEC），当它们离开宿主肠道中的通常储存库时，具有在肠外部位引起疾病的特殊能力。多种证据表明，在尿路感染、败血症和其他肠外感染的人类中遇到的许多exp菌株，特别是最广泛的抗菌素耐药菌株，可能有食用动物来源，并可能通过食物供应传播给人类。本文综述了食源性微生物是人类肠外大肠杆菌感染的重要原因的证据。
Most human extraintestinal Escherichia coli infections, including those involving antimicrobial resistant strains, are caused by the members of a limited number of distinctive E. coli lineages, termed extraintestinal pathogenic E. coli (ExPEC), that have a special ability to cause disease at extraintestinal sites when they exit their usual reservoir in the host's intestinal tract. Multiple lines of evidence suggest that many of the ExPEC strains encountered in humans with urinary tract infection, sepsis, and other extraintestinal infections, especially the most extensively antimicrobial-resistant strains, may have a food animal source, and may be transmitted to humans via the food supply. This review summarizes the evidence that food-borne organisms are a significant cause of extraintestinal E. coli infections in humans.