Recent advances in pharmaceutical applications of chiral capillary electrophoresis.
Recent advances in pharmaceutical applications of chiral capillary electrophoresis.
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DOI：
10.1016/j.jpba.2006.01.035
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发表时间：
2006-04
影响因子：
3.4
通讯作者：
Pham Thi Thanh Ha;J. Hoogmartens;A. Van Schepdael
中科院分区：
文献类型：
--
作者：
Pham Thi Thanh Ha;J. Hoogmartens;A. Van Schepdael
本文综述了2004年1月至2005年6月手性毛细管电泳法在药学领域的研究进展及应用。由于文献的数量巨大，本文的目的是集中于手性分离的主要进展和一些精选的应用，而不是提供所有已发表论文的描述性概述。在此期间发表的几篇优秀评论中也收集了有价值的信息。根据毛细管区带电泳法(CZE)、胶束电动毛细管色谱(MEKC)、微乳液电动毛细管电泳法(MEEKC)对毛细管电泳法的发展进行了分类。在CZE部分，描述了不同类型的手性选择剂，包括环糊精、寡糖和多糖、冠醚、大环抗生素、配体交换系统和蛋白质。本节还包括非水毛细管电泳法。在一个单独的部分中讨论了CE与MS的偶联，然后概述了手性选择性CE的选定的药物应用。最后，对毛细管电泳法在手性分析中的应用进行了展望。
This review article summarizes developments and applications of chiral capillary electrophoresis (CE) in the pharmaceutical field published from January 2004 to June 2005. Due to the tremendous number of publications, this article is aimed to focus on major developments in chiral separations and some selected applications rather than to provide a descriptive overview of all published papers. Valuable information is also collected from several excellent reviews published during this period. Developments are classified according to CE modes, namely capillary zone electrophoresis (CZE), micellar electrokinetic capillary chromatography (MEKC), microemulsion electrokinetic chromatography (MEEKC). In the CZE section, different types of chiral selectors including cyclodextrins, oligo- and polysaccharides, crown ethers, macrocyclic antibiotics, ligand exchange systems and proteins are described. Nonaqueous capillary electrophoresis is also included in this section. Coupling CE to MS is discussed in a separate part, followed by a summary of selected pharmaceutical applications of enantioselective CE. Finally, some conclusions are drawn and prospects of CE in chiral analysis are also drafted.