Sex chromosome abnormalities and psychiatric diseases.
Sex chromosome abnormalities and psychiatric diseases.
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DOI：
10.18632/oncotarget.13962
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发表时间：
2017-01-17
期刊：
影响因子：
--
通讯作者：
Li R
中科院分区：
文献类型：
--
作者：
Zhang X;Yang J;Li Y;Ma X;Li R
最近在精神疾病患者中观察到过度的性染色体异常。目前尚不清楚在一些精神疾病中，性染色体异常是否与性别差异有关。虽然研究表明许多性染色体区域的易感基因与各种精神疾病有关，但也有研究表明，性染色体非整倍体可能是探索精神疾病发病机制的关键。在这篇综述中，我们将概述目前关于性染色体异常与精神分裂症、自闭症、ADHD和情绪障碍相互作用的证据。
Excesses of sex chromosome abnormalities in patients with psychiatric diseases have recently been observed. It remains unclear whether sex chromosome abnormalities are related to sex differences in some psychiatric diseases. While studies showed evidence of susceptibility loci over many sex chromosomal regions related to various mental diseases, others demonstrated that the sex chromosome aneuploidies may be the key to exploring the pathogenesis of psychiatric disease. In this review, we will outline the current evidence on the interaction of sex chromosome abnormalities with schizophrenia, autism, ADHD and mood disorders.