Anti-inflammatory kavalactones from Alpinia zerumbet
Anti-inflammatory kavalactones from Alpinia zerumbet
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DOI：
10.1016/j.fitote.2019.104444
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发表时间：
2020-01-01
期刊：
影响因子：
3.4
通讯作者：
Tanaka, Ken
中科院分区：
文献类型：
--
作者：
Nishidono, Yuto;Okada, Ryo;Tanaka, Ken
紫檀属植物b.l.伯特& R.M.Sm。（姜黄科）是一种多年生植物，原产于东印度群岛，广泛分布于南美洲、大洋洲和亚洲。在中国，这种植物成熟的果实已被用于传统医学。本研究采用LC-MS对同一植物的叶、胎座、果皮和种子甲醇提取物的化学成分进行了比较，并对各提取物和分离化合物的NO抑制活性进行了检测。LC-MS分析的结果是，在叶片、胎盘和果皮的甲醇提取物中检测到卡瓦内酯衍生物（1-6）。其中，化合物6被鉴定为一种新的不对称5,6-脱氢氢化氢环丁烷二聚体。定量分析表明，番石榴果皮甲醇提取物中番石榴内酯衍生物的总含量最高。此外，抗炎活性测定结果显示，果皮提取物的抗炎活性最强。鉴定了莪术提取物中具有抗炎活性的化合物。其中5个是已知的卡瓦内酯衍生物，1个是新的卡瓦内酯衍生物（二聚体C）。结果表明，枇杷果皮富含枇杷内酯衍生物，可作为一种重要的药用资源加以利用。
Alpinia zerumbet (Pers.) B.L.Burtt & R.M.Sm. (Zingiberaceae) is a perennial plant native to the East Indies and is widely distributed in South America, Oceania, and Asia. The mature fruits of the plant have been used in traditional medicine in China. In this study, we compared the chemical constituents in the methanol extracts of the leaves, the placenta, the pericarps, and the seeds obtained from the same plant using LC-MS, and we examined the NO inhibitory activities of the respective extracts and the isolated compounds. As a result of LC-MS analyses, kavalactone derivatives (1-6) were detected in the methanol extracts of the leaves, placenta, and pericarps. Of these, compound 6 was identified as a new asymmetrical cyclobutane dimer of 5,6-dehydrokawain. Quantitative analysis showed that the total amounts of kavalactone derivatives were highest in the methanol extract of the pericarps. Moreover, the results of measurements of the anti-inflammatory activity revealed that the pericarps extract showed the strongest activity. The compounds responsible for the anti-inflammatory activity of the extracts from A. zerumbet were identified. Of these, five were known kavalactone derivatives and one was a new kavalactone derivative (aniba dimer C). The results showed that the pericarps of A. zerumbet are a rich source of kavalactone derivatives, and that the pericarps of A. zerumbet can be utilized as an important medicinal resource.