Contribution to Tumor Angiogenesis From Innate Immune Cells Within the Tumor Microenvironment: Implications for Immunotherapy.
Contribution to Tumor Angiogenesis From Innate Immune Cells Within the Tumor Microenvironment: Implications for Immunotherapy.
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DOI：
10.3389/fimmu.2018.00527
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发表时间：
2018
影响因子：
7.3
通讯作者：
Mortara L
中科院分区：
文献类型：
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作者：
Albini A;Bruno A;Noonan DM;Mortara L
血管生成在促进肿瘤生长和转移中的关键作用已被牢固确立。然而，肿瘤显示出相当大的变化，在血管生成的特点和他们的敏感性，抗血管生成治疗。肿瘤血管生成不仅涉及癌细胞，还涉及各种肿瘤相关白细胞（TAL）和基质细胞。TAL产生趋化因子、细胞因子、蛋白酶、结构蛋白和微囊泡。血管内皮生长因子（VEGF）和炎性趋化因子不仅是主要的促血管生成因子，而且也是免疫调节剂，其增加血管生成并导致免疫抑制。在我们的综述中，我们讨论了先天免疫细胞在肿瘤微环境中对血管生成的调节、特异性特征以及主要参与者的作用：巨噬细胞、中性粒细胞、髓源性抑制细胞和树突状细胞、肥大细胞、γδT细胞、先天淋巴细胞和自然杀伤细胞。抗VEGF或抗炎药物可以平衡免疫抑制微环境与免疫允许微环境。因此，抗VEGF以及抗炎药物可以代表与免疫检查点抑制剂组合的伴侣，增强免疫治疗的效果。
The critical role of angiogenesis in promoting tumor growth and metastasis is strongly established. However, tumors show considerable variation in angiogenic characteristics and in their sensitivity to antiangiogenic therapy. Tumor angiogenesis involves not only cancer cells but also various tumor-associated leukocytes (TALs) and stromal cells. TALs produce chemokines, cytokines, proteases, structural proteins, and microvescicles. Vascular endothelial growth factor (VEGF) and inflammatory chemokines are not only major proangiogenic factors but are also immune modulators, which increase angiogenesis and lead to immune suppression. In our review, we discuss the regulation of angiogenesis by innate immune cells in the tumor microenvironment, specific features, and roles of major players: macrophages, neutrophils, myeloid-derived suppressor and dendritic cells, mast cells, γδT cells, innate lymphoid cells, and natural killer cells. Anti-VEGF or anti-inflammatory drugs could balance an immunosuppressive microenvironment to an immune permissive one. Anti-VEGF as well as anti-inflammatory drugs could therefore represent partners for combinations with immune checkpoint inhibitors, enhancing the effects of immune therapy.
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影响因子：
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作者：
Ammendola M;Leporini C;Marech I;Gadaleta CD;Scognamillo G;Sacco R;Sammarco G;De Sarro G;Russo E;Ranieri G
通讯作者：
Ranieri G
影响因子：
4.1
作者：
Cantoni C;Huergo-Zapico L;Parodi M;Pedrazzi M;Mingari MC;Moretta A;Sparatore B;Gonzalez S;Olive D;Bottino C;Castriconi R;Vitale M
通讯作者：
Vitale M
影响因子：
17.1
作者：
Allen E;Jabouille A;Rivera LB;Lodewijckx I;Missiaen R;Steri V;Feyen K;Tawney J;Hanahan D;Michael IP;Bergers G
通讯作者：
Bergers G
影响因子：
4.8
作者：
Bruno, Antonino;Focaccetti, Chiara;Noonan, Douglas M.
通讯作者：
Noonan, Douglas M.
影响因子：
64.8
作者：
通讯作者：
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