Hydrolytic Degradation and Erosion of Polyester Biomaterials
Hydrolytic Degradation and Erosion of Polyester Biomaterials
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DOI：
10.1021/acsmacrolett.8b00424
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发表时间：
2018-08-01
影响因子：
7.015
通讯作者：
Grunlan, Melissa A.
中科院分区：
文献类型：
--
作者：
Woodard, Lindsay N.;Grunlan, Melissa A.
改善聚酯生物材料降解行为的策略，特别是克服缓慢水解降解的局限性，将扩大其实用性。在此，我们研究了聚酯降解行为的复杂性，其评估和改进策略。控制聚酯降解的因素非常复杂。除了水解不稳定键的半衰期外，还必须考虑一系列相互依赖的材料特性。因此，在降解之前和降解过程中，必须仔细选择用于表征此类材料特性的方法。降解行为的评估由于报告的试验方案的可变性以及需要加速而不是实时体外试验条件而进一步复杂化。最终，通过更好地控制降解行为以及体外模拟降解与体内观察到的降解之间的相关性，可以实现使用聚酯生物材料制备的上级器械的开发。
Strategies to refine the degradation behavior of polyester biomaterials, particularly to overcome the limitations of slow hydrolytic degradation, would broaden their utility. Herein, we examine the complexities of polyester degradation behavior, its assessment, and strategies for refinement. The factors governing polyester degradation are strikingly complex. In addition to the half-life of the hydrolytically labile bond, a series of interdependent material properties must be considered. Thus, methods used to characterize such material properties, both before and during degradation, must be carefully selected. Assessment of degradation behavior is further complicated by the variability of reported test protocols and the need for accelerated rather than real-time in vitro testing conditions. Ultimately, through better control of degradation behavior and correlation of in vitro, simulated degradation to that observed in vivo, the development of superior devices prepared with polyester biomaterials may be achieved.