Different effects of long- and short-acting loop diuretics on survival rate in Dahl high-salt heart failure model rats.
Different effects of long- and short-acting loop diuretics on survival rate in Dahl high-salt heart failure model rats.
复制标题
DOI：
10.1016/j.cardiores.2005.05.023
复制
发表时间：
2005-10
影响因子：
10.8
通讯作者：
Junichi Yoshida;Kazuhiro Yamamoto;T. Mano;Y. Sakata;Mayu Nishio;T. Ohtani;M. Hori;T. Miwa;T. Masuyama
中科院分区：
文献类型：
--
作者：
Junichi Yoshida;Kazuhiro Yamamoto;T. Mano;Y. Sakata;Mayu Nishio;T. Ohtani;M. Hori;T. Miwa;T. Masuyama
目的：比较短效环状利尿剂速尿和长效利尿剂阿佐塞米对高血压心力衰竭大鼠的疗效，以验证长效利尿剂优于短效利尿剂的假说。方法：从8周龄开始喂食8%氯化钠的Dahl盐敏感型大鼠在21周龄(代偿性肥厚期)分为3组：速尿治疗组(40 mg/kg/d)、阿佐塞米治疗组(80 mg/kg/d)和未治疗组。结果：两种药物均能预防31周龄大鼠左室收缩功能障碍和增大，并在一定程度上减轻巨噬细胞的浸润、活性氧的生成和明胶溶解活性。阿佐塞米可将左心室纤维化抑制到对照水平，而速尿则不能。阿佐塞米可改善心肌儿茶酚胺的耗竭，提高存活率。结论：与速尿相比，阿佐塞米可改善心力衰竭大鼠的预后，其部分机制可能是通过抑制心力衰竭时心脏交感神经活动的反射性增加来实现的。目前的发现表明，需要进行临床试验，检查长效和短效利尿剂是否会对心力衰竭患者提供不同的预后。
Objectives:We compared therapeutic effects of furosemide, a short-acting loop diuretic, and azosemide, a long-acting one, in hypertensive heart failure rats to test the hypothesis that long-acting diuretics are superior to short-acting types in heart failure.Methods:Dahl salt-sensitive rats fed an 8% NaCl diet from age 8 weeks were divided at age 21 weeks (compensated hypertrophic stage) into three groups: rats treated with furosemide (40 mg/kg/day), those treated with azosemide (80 mg/kg/day) and untreated rats. Rats fed a 0.3% NaCl diet served as controls.Results:Both medications prevented left ventricular systolic dysfunction and enlargement at age 31 weeks, and attenuated macrophage infiltration, reactive oxygen species generation, and gelatinolytic activity to the same degree. Azosemide suppressed left ventricular fibrosis to the control level, but furosemide did not. Azosemide ameliorated myocardial catecholamine depletion and improved survival rate. Furosemide increased plasma norepinephrine levels and did not exert such beneficial effects.Conclusions:Azosemide provided better prognosis in heart failure rats compared with furosemide, partly through attenuation of the reflex increase in cardiac sympathetic neuronal activity caused by the development of heart failure. The current findings suggest a need for clinical trials examining whether long- and short-acting diuretics provide a different prognosis in patients with heart failure.