Hepatocyte‐derived MANF alleviates hepatic ischaemia‐reperfusion injury via regulating endoplasmic reticulum stress‐induced apoptosis in mice
Hepatocyte‐derived MANF alleviates hepatic ischaemia‐reperfusion injury via regulating endoplasmic reticulum stress‐induced apoptosis in mice
复制标题
肝细胞源性MANF通过调节内质网应激诱导的细胞凋亡减轻小鼠肝缺血再灌注损伤
DOI：
10.1111/liv.14697
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发表时间：
2020-10
影响因子：
6.7
通讯作者：
Yi Yang;Peng Wang;Chaoyi Zhang;Fan Huang;Gao-zong Pang;Chuan-sheng Wei;Changming Lv;Goma Chhetri;Tongcui Jiang;Jun Liu;Yujun Shen;Yuxian Shen
中科院分区：
文献类型：
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作者：
Yi Yang;Peng Wang;Chaoyi Zhang;Fan Huang;Gao-zong Pang;Chuan-sheng Wei;Changming Lv;Goma Chhetri;Tongcui Jiang;Jun Liu;Yujun Shen;Yuxian Shen
内质网（ER）扰动是参与缺血再灌注损伤的新型亚细胞效应物。中脑星形胶质细胞源性神经营养因子（MANF）作为一种内质网应激诱导蛋白，已被证明在缺血性脑损伤中增加。然而，MANF在肝脏缺血再灌注（I/R）损伤中的作用尚未得到研究。
Endoplasmic reticulum (ER) perturbations are novel subcellular effectors involved in the ischaemia‐reperfusion injury. As an ER stress‐inducible protein, mesencephalic astrocyte‐derived neurotrophic factor (MANF) has been proven to be increased during ischaemic brain injury. However, the role of MANF in liver ischaemia reperfusion (I/R) injury has not yet been studied.