THE TOTAL SYNTHESIS OF MYOINOSITOL PHOSPHATES VIA MYOINOSITOL ORTHOFORMATE
THE TOTAL SYNTHESIS OF MYOINOSITOL PHOSPHATES VIA MYOINOSITOL ORTHOFORMATE
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DOI：
10.1039/p19890001423
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发表时间：
1989-08-01
期刊：
影响因子：
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通讯作者：
HUFF, JR
中科院分区：
文献类型：
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作者：
BILLINGTON, DC;BAKER, R;HUFF, JR
肌醇原甲酸酯(4)的新型选择性烷基化已用于制备一系列受保护的肌醇衍生物(5a-e)、(7)、(10)、(12)和(16)。这些中间体已用于肌醇 2-磷酸的有效全合成，(9)；肌醇 4-磷酸，(6)；肌醇1,3-二磷酸，(18)；和肌醇 1,3,4,5-四磷酸 (14)。该报告首次全合成了重要的天然代谢物（14）和（18），并显着改进了（6）和（9）的制备方法。
Novel selective alkylations of myo-inositol orthoformate (4) have been used to prepare a series of protected myo-inositol derivatives, (5a-e), (7), (10), (12), and (16). These intermediates have been used in efficient total syntheses of myo-inositol 2-phosphate, (9); myo-inositol 4-phosphate, (6); myo-inositol 1,3-bisphosphate, (18); and myo-inositol 1,3,4,5-tetrakisphosphate (14). This report represents the first total synthesis of the important natural metabolites (14) and (18) and significantly improved methods of preparation of (6) and (9).