Activity-based sensing fluorescent probes for iron in biological systems.
Activity-based sensing fluorescent probes for iron in biological systems.
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DOI:
10.1016/j.cbpa.2017.12.010
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发表时间:
2018-04
影响因子:
7.8
通讯作者:
Chang CJ
中科院分区:
文献类型:
--
作者:
Aron AT;Reeves AG;Chang CJ
Iron is an essential nutrient for life, and its capacity to cycle between different oxidation states is required for processes spanning oxygen transport and respiration to nucleotide synthesis and epigenetic regulation. However, this same redox ability also makes iron, if not regulated properly, a potentially dangerous toxin that can trigger oxidative stress and damage. New methods that enable monitoring of iron in living biological systems, particularly in labile Fe2+ forms, can help identify its contributions to physiology, aging, and disease. In this review, we summarize recent developments in activity-based sensing (ABS) probes for fluorescence Fe2+ detection.
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