Activity-based sensing fluorescent probes for iron in biological systems.

Activity-based sensing fluorescent probes for iron in biological systems.
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DOI:
10.1016/j.cbpa.2017.12.010
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发表时间:
2018-04
影响因子:
7.8
通讯作者:
Chang CJ
Chang CJ
中科院分区:
生物学2区
文献类型:
--
作者:
Aron AT;Reeves AG;Chang CJ

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铁是生命的必需营养素,其在不同氧化态之间循环的能力是跨越氧运输和呼吸到核苷酸合成和表观遗传调节的过程所必需的。然而,这种相同的氧化还原能力也使铁,如果没有适当的调节,一个潜在的危险毒素,可以引发氧化应激和损伤。能够监测生物系统中铁的新方法,特别是不稳定的Fe2+形式,可以帮助确定其对生理,衰老和疾病的贡献。本文综述了近年来活性传感(ABS)探针在Fe2+荧光检测中的研究进展。
Iron is an essential nutrient for life, and its capacity to cycle between different oxidation states is required for processes spanning oxygen transport and respiration to nucleotide synthesis and epigenetic regulation. However, this same redox ability also makes iron, if not regulated properly, a potentially dangerous toxin that can trigger oxidative stress and damage. New methods that enable monitoring of iron in living biological systems, particularly in labile Fe2+ forms, can help identify its contributions to physiology, aging, and disease. In this review, we summarize recent developments in activity-based sensing (ABS) probes for fluorescence Fe2+ detection.
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