OVARIAN ENDOMETRIOID CARCINOMAS RESEMBLING SEX CORD STROMAL TUMORS - A CLINICOPATHOLOGICAL ANALYSIS OF 13 CASES
OVARIAN ENDOMETRIOID CARCINOMAS RESEMBLING SEX CORD STROMAL TUMORS - A CLINICOPATHOLOGICAL ANALYSIS OF 13 CASES
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DOI：
10.1097/00000478-198209000-00003
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发表时间：
1982-01-01
影响因子：
5.6
通讯作者：
SCULLY, RE
中科院分区：
文献类型：
--
作者：
YOUNG, RH;PRAT, J;SCULLY, RE
本文报道了13例卵巢子宫内膜样癌，其主要形态与性索间质肿瘤相似。在这些肿瘤中，8例被转诊病理学家误解为性索间质肿瘤，几乎都是支持- leydig细胞类型。后一种诊断是由小管状腺体或弯曲的，细长的实管状结构的优势。在4例中，肿瘤基质中存在黄体细胞导致了误解。然而，每个标本都具有1个或多个特征，包括与典型子宫内膜样腺癌相似的大管状腺体、鳞状分化灶、腔内黏液积聚和腺纤维瘤成分。两个肿瘤位于双侧。患者的年龄范围（58-86岁）与通常年轻得多的Sertoli-Leydig细胞肿瘤患者明显不同，相关的临床表现也与卵巢癌一般不同。未观察到雄激素作用，仅1例有明显的雌激素表现。
Thirteen endometrioid carcinomas of the ovary with predominant patterns resembling those of sex cord-stromal tumors are reported. Of these neoplasms, 8 were misinterpreted by the referring pathologists as sex cord-stromal tumors, almost always of the Sertoli-Leydig cell type. The latter diagnosis was suggested by a predominance of small tubular glands or winding, elongated solid tubular structures. In 4 cases, the presence of luteinized cells in the tumor stroma contributed to the misinterpretation. Each specimen, however, had 1 or more features establishing its endometrioid nature, including large tubular glands resembling those of the typical endometrioid adenocarcinoma, foci of squamous differentiation, luminal mucin accumulation, and adenofibromatous components. Two tumors were bilateral. The age range of the patients (from 58-86 yr) differed markedly from that of patients with Sertoli-Leydig cell tumors, who are generally much younger, as did the associated clinical manifestations, which were those of ovarian cancer in general. No androgenic effects were observed and estrogenic manifestations were evident in only 1 of the cases.