The effect of 15-lipoxygenase-1 expression on cancer cells.
The effect of 15-lipoxygenase-1 expression on cancer cells.
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DOI：
10.1007/s11934-002-0066-8
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发表时间：
2002-06-01
影响因子：
2.6
通讯作者：
Eling, Thomas E
中科院分区：
文献类型：
--
作者：
Kelavkar, Uddhav;Glasgow, Wayne;Eling, Thomas E
脂肪氧合酶将多不饱和脂肪酸氧化代谢成丰富的生物活性产物。脂氧合酶家族的一种酶，花生四烯酸15-脂氧合酶-1(花生四烯酸：氧15-氧化还原酶，EC 1.13.11.33)，与多种形式的上皮细胞癌有关，为探索其在癌症进展和转移中的作用提供了理论基础。因此，15-LO-1可能是肿瘤生长和扩散的标志物。15-LO-1表达的重要性是由其代谢产物亚油酸赋予的，亚油酸产生13-(S)-羟基十八烯酸(13-(S)-HODE)。为了最大限度地了解脂氧合酶和环氧合酶在癌症中的作用，有必要将它们的代谢途径与各自的表达水平相关联，而不是在明显不存在的情况下夸大酶的存在或不存在或其功能。同样重要的是要认识到，这些酶的某些形式甚至可能与人类疾病无关。虽然单个基因不太可能足以解释癌症的复杂病因，但15-LO-1的过度表达显然是细胞增殖过程中的一个关键组成部分。这篇文章分为三个部分，强调15-LO-1在前列腺癌、结直肠癌和乳腺癌中的关键作用。
Lipoxygenases oxidatively metabolize polyunsaturated fatty acids to a rich spectrum of biologically active products. One enzyme of the lipoxygenase family, Arachidonate 15-lipoxygenase-1 (arachidonate:oxygen 15-oxidoreductase, EC 1.13.11.33), is implicated in several forms of epithelial cell cancers, and provides a rationale for exploring its role in the progression and metastasis of cancers. Thus, 15-LO-1 could be a marker of the growth and spread of cancers. The importance of 15-LO-1 expression is imparted by its metabolic product of linoleic acid, yielding 13-(S)-hydroxyoctadecadienoic acid (13-(S)-HODE). In order to maximize our understanding of the roles of lipoxygenases and cyclooxygenases in cancer, it is necessary to correlate their metabolic pathways to the respective expression levels, and not exaggerate the presence or absence of an enzyme or its function when it clearly is not there. It is also important to acknowledge that some forms of these enzymes may not even be relevant to human disease. Although it is unlikely that any single gene is sufficient to account for the complex etiology of cancer, 15-LO-1 overexpression is clearly a key component in the cell proliferation process. This article is divided into three sections emphasizing the key role of 15-LO-1 in prostate, colorectal, and breast cancers.