Transforming G proteins
Transforming G proteins
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DOI：
10.1038/sj.onc.1204274
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发表时间：
2001-03-26
期刊：
影响因子：
8
通讯作者：
Dhanasekaran, N
中科院分区：
文献类型：
--
作者：
Radhika, V;Dhanasekaran, N
异源三聚体鸟嘌呤核苷酸结合蛋白，通常称为G蛋白，形成信号转导蛋白的超家族。G蛋白是由α、β和γ亚基的单体组成，β和γ亚基紧密结合。由适当的“信号”激活的受体与特异性G蛋白催化相互作用，以介导G蛋白α亚基的GDP/GTP结合位点处的鸟嘌呤核苷酸交换，从而将结合的GDP置换为GTP。G蛋白α亚基的GTP结合形式和在某些情况下游离β γ亚基通过改变特异性效应分子的活性来启动细胞应答，最近的研究表明，这些蛋白的异步激活可以导致不同类型细胞的致癌转化，G蛋白调节各种细胞功能的机制似乎涉及不同信号通路之间的复杂网络。本文综述了这些转化G蛋白参与细胞增殖调控的信号转导机制。
Heterotrimeric guanine nucleotide binding proteins, commonly known as G proteins form a super-family of signal transduction proteins. They are peripherally associated with the plasma membrane and provide signal coupling to seven transmembrane surface receptors, G proteins are composed of monomers of alpha, beta, and gamma subunits, The beta- and gamma -subunits are tightly associated. The receptors activated by the appropriate 'signal', interact catalytically with specific G-proteins to mediate guanine nucleotide exchange at the GDP/GTP binding site of the G-protein alpha -subunits, thus displacing the bound GDP for GTP, The GTP bound form of the g-protein alpha -subunit and in some cases the free beta gamma -subunits initiate cellular response by altering the activity of specific effector molecules, Recent studies have indicated that the asynchronous activation of these proteins can lead to the oncogenic transformation of different cell types, The mechanism by which G-proteins regulate the various cell functions appear to involve a complex net-working between different signaling pathways. This review summarizes the signaling mechanisms involved in the regulation of cell proliferation by these transforming G proteins.