Effects of lifestyle modification on central artery stiffness in metabolic syndrome subjects with pre-hypertension and/or pre-diabetes
Effects of lifestyle modification on central artery stiffness in metabolic syndrome subjects with pre-hypertension and/or pre-diabetes
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DOI：
10.1016/j.diabres.2008.11.016
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发表时间：
2009-02-01
影响因子：
5.1
通讯作者：
Petrella, Robert J.
中科院分区：
文献类型：
--
作者：
Aizawa, Kunihiko;Shoemaker, J. Kevin;Petrella, Robert J.
目的：探讨家庭医生制定的为期24周的生活方式干预对代谢综合征(MS)合并高血压前期和/或糖尿病前期患者颈动脉硬度的影响。方法：将63例有高血压前期和/或糖尿病前期的中老年患者分为无MS组(MS-)和MS+组(MS+)。分别在基线、8周和24周生活方式干预后测定MS成分和颈动脉超声硬度。结果：干预24周后，MS+患者的颈动脉扩张性较基线显著增加(0.191+/-0.012 vs 0.143+/-0.011，1/mm Hgx10(-2)，p<；0.05)。同样，在干预24周后，MS+的p僵硬指数降低(9.8+/-1.1比12.5+/-1.1 AU，p<；0.05)。干预后，MS+患者腰围、血压和空腹血糖水平均下降(均P<0.05)，13例MS+患者无MS。结论：干预结果显示MS患者颈动脉僵硬程度降低，部分MS成分改善，提示我们的生活方式调整策略对MS患者的中央动脉僵硬和MS成分有良好的效果。(C)2008爱思唯尔爱尔兰有限公司。保留所有权利。
Aims: To examine the effects of a 24-week lifestyle intervention prescribed by family doctors on carotid artery stiffness in metabolic syndrome (MS) subjects with pre-hypertension and/or pre-diabetes.Methods: Sixty-three middle-aged and older subjects with pre-hypertension and/or prediabetes were divided into subjects without MS (MS-) and with MS (MS+). MS components and carotid artery stiffness by ultrasound were determined at baseline, at 8 weeks, and following the 24 weeks of lifestyle intervention. Family doctors prescribed an individually customized lifestyle prescription for aerobic exercise and Mediterranean-style diet.Results: Carotid artery distensibility significantly increased in MS+ following the 24 weeks of intervention compared with baseline (0.191 +/- 0.012 vs. 0.143 +/- 0.011, 1/mmHg x 10(-2), p < 0.05). Similarly, p stiffness index decreased in MS+ following the 24 weeks of intervention (9.8 +/- 1.1 vs. 12.5 +/- 1.1 AU, p < 0.05). Following the intervention, waist circumference, BP and fasting glucose levels reduced in MS+ (all p < 0.05), and 13 MS+ subjects were free from MS.Conclusions: The results show the reduction of carotid artery stiffness and the improvement of some MS components in MS subjects, suggesting a favorable effect of our lifestyle modification strategy on central artery stiffness as well as MS components in MS subjects. (C) 2008 Elsevier Ireland Ltd. All rights reserved.