Emerging therapeutic delivery capabilities and challenges utilizing enzyme/protein packaged bacterial vesicles
Emerging therapeutic delivery capabilities and challenges utilizing enzyme/protein packaged bacterial vesicles
复制标题
DOI：
10.4155/tde.15.40
复制
发表时间：
2015-07-01
影响因子：
4.2
通讯作者：
Walper, Scott A.
中科院分区：
文献类型：
--
作者：
Alves, Nathan J.;Turner, Kendrick B.;Walper, Scott A.
基于纳米颗粒的疗法有望在疾病治疗中发挥关键作用。这些复杂的多功能药物输送载体可被动和主动靶向输送多种小分子、肽和蛋白质衍生药物。本文将首先讨论一些当前最先进的纳米颗粒类别（树枝状聚合物、脂质基纳米颗粒、聚合物纳米颗粒和无机纳米颗粒），重点介绍与其实施相关的优点/缺点。然后，我们将讨论一类新兴的纳米颗粒疗法，即细菌外膜囊泡，它可以提供许多纳米颗粒的优点，同时简化组装。通过分子生物学技术；外膜囊泡劫持可能允许严格控制纳米颗粒的生产，从而允许细菌完全合成靶向蛋白质包装的纳米颗粒。
Nanoparticle-based therapeutics are poised to play a critical role in treating disease. These complex multifunctional drug delivery vehicles provide for the passive and active targeted delivery of numerous small molecule, peptide and protein-derived pharmaceuticals. This article will first discuss some of the current state of the art nanoparticle classes (dendrimers, lipid-based, polymeric and inorganic), highlighting benefits/drawbacks associated with their implementation. We will then discuss an emerging class of nanoparticle therapeutics, bacterial outer membrane vesicles, that can provide many of the nanoparticle benefits while simplifying assembly. Through molecular biology techniques; outer membrane vesicle hijacking potentially allows for stringent control over nanoparticle production allowing for targeted protein packaged nanoparticles to be fully synthesized by bacteria.