Naturally occurring B-cell autoreactivity: A critical overview
Naturally occurring B-cell autoreactivity: A critical overview
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DOI：
10.1016/j.jaut.2007.07.010
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发表时间：
2007-12-01
影响因子：
12.8
通讯作者：
Lymberi, Peggy
中科院分区：
文献类型：
--
作者：
Avrameas, Stratis;Ternynck, Therese;Lymberi, Peggy
在免疫学研究的一个世纪中，科学知识和由此产生的影响取得了显著进展。与此同时，也得到了一些相互矛盾和似乎对立的结果。许多人仍然认为“自身免疫”一词是与免疫病理状态直接相关的术语。然而，强有力的证据表明，不仅免疫系统能够识别自身成分，而且这种特性对于体内平衡也是必不可少的。免疫系统的这种自我识别特性的直接或间接改变可能有助于病理学。在这篇综述中，自然发生的B细胞自身反应性在健康以及疾病领域的最新进展，并进行了讨论。(c)2007爱思唯尔有限公司保留所有权利。
In over one century of research in immunology marked progress in the scientific knowledge and the implications derived from it has been made. At the same time several contradictory and seemingly opposing results have been obtained. The term autoimmunity is still conceived by many as a term directly related to an immunopathological state. However, strong evidence exist that not only the immune system is able to recognize self-constituents, but it appears also that this property is essential for homeostasis. Direct or indirect alterations of such self-recognition properties of the immune system may contribute to pathology. In this review, the most recent advances in the field of naturally occurring B-cell autoreactivity in health as well as in disease are presented and discussed. (c) 2007 Elsevier Ltd. All rights reserved.