Clinical pharmacodynamics of quinolones
Clinical pharmacodynamics of quinolones
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DOI：
10.1016/s0891-5520(03)00061-8
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发表时间：
2003-09-01
影响因子：
4.4
通讯作者：
Owens, RC
中科院分区：
文献类型：
--
作者：
Ambrose, PG;Bhavnani, SM;Owens, RC
药代动力学-药效学（PK-PD）描述了药物浓度与药物药理学或毒理学效应之间的关系。本文重点介绍了基本的PK-PD概念，因为它们适用于喹诺酮类抗菌药物。这些知识的应用对临床医生、药物开发者和监管者具有巨大价值，因为PK-PD原理构成了现代抗菌化疗的基础。
Pharmacokinetics-pharmacodynamics (PK-PD) describes the relationship between drug concentrations and the agent's pharmacologic or toxicologic effects. This article focuses on fundamental PK-PD concepts as they apply to quinolone antimicrobial agents. The application of this knowledge is of tremendous value to the clinician, drug developer, and regulator because PK-PD principles form the very basis of modern antimicrobial chemotherapeutics.