Determinants of Plasma PFOA and PFOS Levels Among 652 Danish Men
Determinants of Plasma PFOA and PFOS Levels Among 652 Danish Men
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DOI：
10.1021/es100626h
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发表时间：
2011-10-01
影响因子：
11.4
通讯作者：
Raaschou-Nielsen, Ole
中科院分区：
文献类型：
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作者：
Eriksen, Kirsten T.;Sorensen, Mette;Raaschou-Nielsen, Ole
全氟辛酸盐（PFOA）和全氟辛烷磺酸盐（PFOS）用于各种工业和消费品，并已在世界范围内的人类血液中检测到。人类接触的来源没有得到很好的描述，但饮食摄入被认为是一个重要来源。在这项对来自饮食、癌症和健康队列的652名丹麦男性的研究中，我们检查了10个主要饮食组的摄入量、自来水饮料、酒精消费量、烹饪方法、地理区域、年龄、吸烟状况和BMI，作为PFOA和PFOS血浆水平的潜在决定因素。与生活在哥本哈根地区相比，生活在奥胡斯地区的人血浆中的全氟辛酸和全氟辛烷磺酸水平较高，从不吸烟的人血浆中的全氟辛酸和全氟辛烷磺酸水平高于目前吸烟的人。与其他烹饪方法相比，油炸是全氟辛酸和全氟辛烷磺酸含量的决定因素。BMI和饮酒量与这两种化合物呈负相关。在饮食组中，只有蛋类摄入量与全氟辛烷磺酸血浆水平显著正相关。在今后的研究中，应测量空气、灰尘和水样本中的全氟辛酸和全氟辛烷磺酸水平，以进一步阐明接触来源;需要更详细地研究通过饮食接触。我们发现从不吸烟者体内的PFOA和PFOS负担较高，这也值得进一步评估。
Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are used in a variety of industrial and consumer products and have been detected worldwide in human blood. The sources for human exposure are not well described, but dietary intake is suggested as an important source. In this study of 652 Danish men from the Diet, Cancer and Health cohort, we examined intake of 10 major dietary groups, tap water drinks, alcohol consumption, cooking method, geographical area, age, smoking status, and BMI as potential determinants of PFOA and PFOS plasma levels. Living in the Aarhus area was associated with higher PFOA and PFOS plasma levels compared with living in the Copenhagen area, and never smokers had higher levels than current smokers. Frying as compared with other cooking methods was a determinant of PFOA and PFOS levels. BMI and alcohol consumption were inversely associated with both compounds. Among the dietary groups, only intake of eggs was significantly positively associated with PFOS plasma levels. In future studies, PFOA and PFOS levels in air, dust and water samples should be measured to elucidate further the sources of exposure; exposure through diet needs to be studied in greater detail. Our finding of a higher body burden of PFOA and PFOS among never smokers also warrants further evaluation.