Rapid prototyping of microfluidic devices with a wax printer
Rapid prototyping of microfluidic devices with a wax printer
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DOI：
10.1039/b617764f
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发表时间：
2007-01-01
期刊：
影响因子：
6.1
通讯作者：
Backhouse, Christopher J.
中科院分区：
文献类型：
--
作者：
Kaigala, Govind V.;Ho, Sunny;Backhouse, Christopher J.
我们展示了一种快速和廉价的方法，用于制造高分辨率的聚二甲基硅氧烷（PDMS）为基础的微流控器件。整个制作过程可以在几个小时（或更少）内完成，除了消费级蜡打印机之外没有任何专门设备。通过这种方法产生的通道是足够高的质量，我们能够证明使用毛细管电泳（CE）的DNA片段的大小和分离没有明显的损失，发现与传统的电泳方法制造的玻璃芯片的分辨率。我们相信，这种方法将大大提高快速成型方法的可及性。
We demonstrate a rapid and inexpensive approach for the fabrication of high resolution poly( dimethylsiloxane) (PDMS)-based microfluidic devices. The complete process of fabrication could be performed in several hours ( or less) without any specialized equipment other than a consumer-grade wax printer. The channels produced by this method are of high enough quality that we are able to demonstrate the sizing and separation of DNA fragments using capillary electrophoresis (CE) with no apparent loss of resolution over that found with glass chips fabricated by conventional photolithographic methods. We believe that this method will greatly improve the accessibility of rapid prototyping methods.