Animal Enterotoxigenic Escherichia coli.
Animal Enterotoxigenic Escherichia coli.
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DOI：
10.1128/ecosalplus.esp-0006-2016
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Schifferli DM
中科院分区：
文献类型：
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作者：
Dubreuil JD;Isaacson RE;Schifferli DM
产肠毒素大肠杆菌（ETEC）是大肠杆菌最常见的病因。农场动物大肠杆菌腹泻。ETEC的特征在于能够产生两种类型的毒力因子;促进与肠道定植的特异性肠上皮细胞受体结合的粘附素和负责液体分泌的肠毒素。最佳表征的粘附素在菌毛的情况下表达，例如F4（也称为K88）、F5（K99）、F6（987 P）、F17和F18菌毛。一旦在动物小肠中建立，ETEC就会产生导致腹泻的肠毒素。肠毒素分为两大类：由一个活性亚基和五个结合亚基（LT）组成的热不稳定毒素，以及小多肽（STa、STb和EAST 1）的热稳定毒素。本章描述了动物ETEC的疾病和发病机制，这些细菌的相应毒力基因和蛋白产物，它们在动物宿主中的调控和靶点，以及作用机制。此外，疫苗，抑制剂，益生菌和基因组学鉴定的潜在新靶点的鉴定在动物ETEC的背景下提出。
Enterotoxigenic Escherichia coli (ETEC) is the most common cause of E. coli diarrhea in farm animals. ETEC are characterized by the ability to produce two types of virulence factors; adhesins that promote binding to specific enterocyte receptors for intestinal colonization and enterotoxins responsible for fluid secretion. The best-characterized adhesins are expressed in the context of fimbriae, such as the F4 (also designated K88), F5 (K99), F6 (987P), F17 and F18 fimbriae. Once established in the animal small intestine, ETEC produces enterotoxin(s) that lead to diarrhea. The enterotoxins belong to two major classes; heat-labile toxin that consist of one active and five binding subunits (LT), and heat-stable toxins that are small polypeptides (STa, STb, and EAST1). This chapter describes the disease and pathogenesis of animal ETEC, the corresponding virulence genes and protein products of these bacteria, their regulation and targets in animal hosts, as well as mechanisms of action. Furthermore, vaccines, inhibitors, probiotics and the identification of potential new targets identified by genomics are presented in the context of animal ETEC.