Glutathione peroxidase enzyme activity in aging
Glutathione peroxidase enzyme activity in aging
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DOI：
10.1093/gerona/63.5.505
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发表时间：
2008-05-01
影响因子：
5.1
通讯作者：
Walston, Jeremy D.
中科院分区：
文献类型：
--
作者：
Espinoza, Sara E.;Guo, Hongfei;Walston, Jeremy D.
背景据推测，自由基损伤有助于衰老。抗氧化酶谷胱甘肽过氧化物酶（GPx）活性的降低可能导致自由基的增加。我们假设GPx活性随着年龄的增长而下降，在老年妇女与残疾。全血GPx活性是在妇女健康和老龄化研究1（一组残疾社区老年妇女）的基线储存样本中测量的。采用线性回归确定GPx活性与年龄之间的横截面关系，调整血红蛋白、冠心病、糖尿病、硒和体重指数。601名参与者有完整的人口统计学，疾病和实验室信息。GPx与年龄呈负相关（回归系数=-2.9，p <0.001），表明年龄每增加1岁，GPx活性降低2.9 μ mol/min/L。这一发现在调整血红蛋白、冠心病、糖尿病和硒后仍然显著，但在调整体重指数和体重减轻后不显著。这是第一项研究在老年残疾和慢性疾病人群中检查年龄和GPx活性之间的关联。这些研究结果表明，在65岁以后，GPx活性随着老年残疾妇女的年龄而下降。这种下降似乎与以前报道的改变GPx活性的疾病无关。对不同老年人群中GPx活性和其他抗氧化酶的纵向检查将为这些系统中与年龄和疾病相关的变化提供额外的见解。
Background. It is hypothesized that free radical damage contributes to aging. Age-related decline in activity of the antioxidant enzyme glutathione peroxidase (GPx) may contribute to increased free radicals. We hypothesized that GPx activity decreases with age in a population of older women with disability.Methods. Whole blood GPx activity was measured in baseline stored samples from participants in the Women's Health and Aging Study 1, a cohort of disabled community-dwelling older women. Linear regression was used to determine cross-sectional associations between GPx activity and age, adjusting for hemoglobin, coronary disease, diabetes, selenium, and body mass index.Results. Six hundred one participants had complete demographic, disease, and laboratory information. An inverse association was observed between GPx and age (regression coefficient = -2.9, p < .001), indicating that for each 1-year increase in age, GPx activity decreased by 2.9 mu mol/min/L. This finding remained significant after adjustment for hemoglobin, coronary disease, diabetes, and selenium, but not after adjustment for body mass index and weight loss.Conclusion. This is the first study to examine the association between age and GPx activity in an older adult cohort with disability and chronic disease. These findings suggest that, after age 65, GPx activity declines with age in older women with disability. This decline does not appear to be related to diseases that have been previously reported to alter GPx activity. Longitudinal examination of GPx activity and other antioxidant enzymes in diverse populations of older adults will provide additional insight into age- and disease-related changes in these systems.