Novel insights into atopic dermatitis.
Novel insights into atopic dermatitis.
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DOI：
10.1016/j.jaci.2022.10.023
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发表时间：
2022-11
期刊：
影响因子：
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通讯作者：
Charles F. Schuler;A. Billi;E. Maverakis;L. Tsoi;J. Gudjonsson
中科院分区：
文献类型：
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作者：
Charles F. Schuler;A. Billi;E. Maverakis;L. Tsoi;J. Gudjonsson
特应性皮炎（AD）的病理生理学和治疗的最新研究显示了显着的进展。免疫系统的越来越多的方面与AD有关，包括上皮屏障、TH2细胞因子和肥大细胞。生物细胞因子和受体拮抗剂以及Janus激酶抑制剂在治疗方面取得了重大进展。我们专注于这些领域，并解决AD流行病学，生物标志物，内型，预防和合并症的新见解。展望未来，我们预计未来的机制见解和治疗进展将扩大医生诊断和管理AD患者的能力，并可能找到治疗这种慢性疾病的方法。
Recent research into the pathophysiology and treatment of atopic dermatitis (AD) has shown notable progress. An increasing number of aspects of the immune system are being implicated in AD, including the epithelial barrier, TH2 cytokines, and mast cells. Major advances in therapeutics were made in biologic cytokine and receptor antagonists and among Janus kinase inhibitors. We focus on these areas and address new insights into AD epidemiology, biomarkers, endotypes, prevention, and comorbidities. Going forward, we expect future mechanistic insights and therapeutic advances to broaden physicians ability to diagnose and manage AD patients, and perhaps to find a cure for this chronic condition.